无食症神经性青少年中奖励和焦虑的多变量神经模式
Hayden J Peel1,2, Nicco Reggente3, Michael Strober4
1Centre for Addiction and Mental Health, Toronto, ON, Canada.
bioRxiv : the preprint server for biology
|August 2, 2024
概括
与对照组相比,患有神经性厌食症 (AN) 的青少年女孩对奖励的脑反应不那么一致. 在这两组中,焦虑并没有显著改变这些与奖励相关的神经模式.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 心理学 心理学 心理学
背景情况:
- 神经性厌食症 (AN) 经常与高度焦虑和改变的奖励处理有关.
- 了解AN中奖励反应的神经基础对于开发有效的治疗方法至关重要.
研究的目的:
- 调查与AN的青少年女孩奖励处理的多变量神经模式.
- 检查焦虑如何影响AN个体对奖励的神经反应.
主要方法:
- 功能磁共振成像 (fMRI) 数据是在金钱奖励任务期间收集的.
- 使用代表性相似性分析来评估奖励回路中神经反应的试验对试验一致性.
- 参与者包括25名患有AN的青少年女孩和22名健康对照,在奖励之前接触过中性或引起焦虑的单词.
主要成果:
- 与对照组相比,在中性条件下获得奖励的参与者表现出较低的神经代表性相似性.
- 对照组在关键奖励区域 (核,杏仁体,轨道前皮层) 中显示出显著的代表性相似性,但在AN组中没有这种相似性.
- 虽然这两组在前额认知控制区域都表现出与奖励相关的活动,但对照组的程度更大. 引起焦虑的词语对组之间的奖励处理没有产生差异性的影响.
结论:
- 患有AN的人在中性状态下对奖励接收的神经反应不太一致,影响了奖励和认知控制电路.
- 在这项研究中,焦虑并没有显著调节奖励处理.
- 研究结果表明,在神经性厌食症中,以奖励为重点的干预措施可能是潜在的目标.
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