通过使用未经修改的胺合钻石电极,在药物配方中快速简单地检测阿凡纳菲尔的电压测量
Hoshyar Saadi Ali1, Hemn A H Barzani2, Yavuz Yardım3
1Department of Analytical Chemistry, Faculty of Science, Van Yuzuncu Yil University, 65080 Van, Turkey.
ADMET & DMPK
|August 2, 2024
概括
使用未经修改的胺合钻石电极的新型简单电压测量方法可以准确检测阿瓦纳菲尔 (AVN). 这种敏感的技术为分析药物配方中的AVN提供了快速和可行的方法.
科学领域:
- 电化学 电化学 电化学
- 分析化学 分析化学
- 药品分析 药品分析
背景情况:
- 勃起功能障碍是常见的,并用药物治疗,如阿瓦纳菲尔 (AVN).
- 开发用于AVN检测的快速,灵敏的方法至关重要.
- 固酶-5抑制剂被广泛用于治疗勃起功能障碍.
研究的目的:
- 开发一种新,灵敏和简单的电子分析方法来量化阿凡纳菲尔 (AVN).
- 在AVN分析中使用未经修改的添加钻石 (BDD) 电极.
- 建立一种可行的方法来确定药品中的AVN.
主要方法:
- 使用循环电压测量和方波电压测量进行电压测量分析.
- 使用未经修改的添加钻石 (BDD) 电极.
- 使用pH值为4.0的布里顿-罗宾逊缓冲器,以实现最佳的信号检测.
主要成果:
- 在布里顿-罗宾逊缓冲器 (pH4.0) 中,在+1.44 V (vs. Ag/AgCl) 时观察到AVN氧化不可逆转的阳极峰值.
- 方波电压测量为AVN量化提供了在宽动态范围 (0.530.0 μg mL-1) 内的线性响应.
- 实现了低检测极限 (0.14μg mL-1),显示出高灵敏度和适合制药分析.
结论:
- 开发的电压测量方法为AVN确定提供了一种简化,快速和资源高效的方法.
- 消除电极修改可以提高该方法的可行性和实用性.
- 该技术适用于药物配方中精确的AVN含量分析.
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