无标签和基于标签的电化学检测疾病生物标记蛋白质
Tias Febriana Hanifa Lestari1, Irkham Irkham1, Uji Pratomo1
1Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, 45363, Indonesia.
ADMET & DMPK
|August 2, 2024
概括
电化学生物传感器通过检测蛋白质生物标志物,提供快速,经济高效的疾病诊断. 本综述详细介绍了分析这些关键健康指标的无标签和标签方法.
科学领域:
- 生物医学工程 生物医学工程
- 分析化学 分析化学
- 纳米技术纳米技术
背景情况:
- 生物传感器将生物传感元件与传感器集成,用于健康监测.
- 电化学检测因其成本效益,简单性和便携性而受到青.
- 生物传感器检测到的蛋白质生物标志物提供了疾病的客观,非侵入性指标.
研究的目的:
- 在电化学生物传感器中全面审查无标签和标签检测方法.
- 突出这些生物传感器在蛋白质生物标记物检测方面的近期应用 (过去六年).
- 讨论影响无标签和标签检测策略之间的选择因素.
主要方法:
- 无标签检测机制的文档,在分析物结合时产生信号.
- 使用分子标签 (酶,纳米颗粒,光标签) 的标记检测方法的文件.
- 文献审查,重点关注用于蛋白质生物标志物分析的电化学生物传感器应用.
主要成果:
- 电化学生物传感器采用无标签和标签技术,可有效检测与疾病相关的蛋白质生物标志物.
- 检测方法的选择取决于分析物质特性,生物传感器设计和所需的性能指标.
- 最近的进展已经扩大了这些生物传感器用于早期疾病诊断的实用性.
结论:
- 电化学生物传感器是用于蛋白质生物标记物检测的多功能工具,可实现早期疾病诊断.
- 无论是无标签的方法还是有标签的方法,都根据应用程序提供了明显的优势.
- 生物传感器技术的持续研究有望进一步提高灵敏度,特异性和临床实用性.
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