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药物的冷激光烧结:朝着碳中和的制药印刷

Moe Elbadawi¹, Hanxiang Li², Paromita Ghosh²

¹School of Biological and Behavioural Sciences, Queen Mary University of London, Mile End Road, London E1 4DQ, United Kingdom.

ACS sustainable chemistry & engineering

|August 2, 2024

概括

冷激光烧结 (CLS) 为3D打印药品提供了传统选择性激光烧结 (SLS) 的可持续替代方案. 这种新的方法可以显著降低能源消耗和碳排放,同时保持药物配方质量.

科学领域:

制药技术制药技术制药技术
增材制造增材制造是一种增材制造.
绿色化学是一种绿色化学.

背景情况:

选择性激光烧结 (SLS) 能够实现个性化的3D打印药品,但由于粉床加热,需要高能耗,从而产生显著的碳足迹.
这种能源需求阻碍了SLS在药物制造中的工业化应用.

研究的目的:

引入和评估冷激光烧结 (CLS) 作为3D打印制药剂量表单的能效替代方案.
为了评估没有粉末床预热的烧结的可行性.

主要方法:

研究了单独使用激光功率在室温下化制药粉末颗粒的方法.
经过测试的基于Kolicoat IR和Eudragit L100-55的配方.
评估了CLS打印配方的机械性能 (柔性强度) 和分解时间.

主要成果:

激光功率高于1.8W在室温下成功烧结配方.
与传统的SLS相比,CLS减少了99%的碳排放.
通过CLS打印的配方表现出与SLS打印相似的微观结构,分解和药物分散,具有更高药物负载的潜力.
激光功率的增加增强了曲强度,但也增加了分解时间.

结论:

冷激光烧结 (CLS) 是一种可行的,环保的方法,用于制药3D打印.
CLS最大限度地减少了能源使用和碳足迹,与工业5.0原则保持一致.
该过程产生了适合工业应用的高质量制药配方.

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