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内生菌:乳腺癌治疗方法和药物开发的未来前景

Sherin Varghese¹, M S Jisha¹, K C Rajeshkumar²

¹School of Biosciences, Mahatma Gandhi University, Kottayam, Kerala, 686560, India.

|August 2, 2024

概括

来自药用植物的内菌为新型乳腺癌治疗提供了有希望的来源. 这次审查强调了它们的生物活性化合物和开发新抗癌药物的潜力.

科学领域:

药理学药理学是指药理学的学科.
菌群学菌群学菌群学是指菌群学
在瘤学瘤学.

背景情况:

乳腺癌仍然是全球女性癌症相关死亡的主要原因,需要新的治疗策略.
内生真菌,在药用植物中居住的共生微生物,产生各种生物活性化合物,具有显著的制药潜力.
这些真菌内细胞越来越被认为是发现新抗癌剂的宝贵资源.

研究的目的:

审查内菌作为开发乳腺癌治疗创新抗癌药物的来源的潜力.
从1990年到2022年收集和分析来自内性真菌的生物活性代谢物,这些代谢物具有针对乳腺癌的治疗潜力.
讨论目前的趋势,挑战和未来的前景,以内菌为基础的乳腺癌药物发现.

主要方法:

从1990年到2022年对科学数据库 (如PubMed,Scopus) 的综合文献综述.
鉴定和编译内性真菌及其生物活性代谢物,报告其对乳腺癌的抗癌活性.
分析当前的研究趋势,包括人工智能,机器学习和基于内菌的药物发现中的多omics方法.

主要成果:

来自药用植物的广泛的内性真菌含有具有强大抗癌作用的生物活性化合物,可对抗乳腺癌细胞系.
几种关键的内性代谢物在临床前 (体内) 研究中显示出有希望的结果,并且正在向临床试验迈进.
该评论详细介绍了特定的化合物,它们的来源,作用机制和针对各种乳腺癌模型的疗效.

结论:

内生菌是发现新型,有效和潜在的更安全的抗癌药物用于乳腺癌治疗的丰富且未被探索的储存库.
集成人工智能和多组学等先进技术可以加速这些真菌衍生疗法的识别和开发.
进一步的研究和临床调查至关重要,以充分利用内菌在抗击乳腺癌方面的治疗潜力.

关键词:

抗癌化合物是一种抗癌化合物.乳腺癌内性真菌药用植物

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