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在患有多发性硬化症的人群中,在异常肌肉训练课程后,系统性细胞因子没有立即变化

Yasmin Alt¹, Monique Wochatz^2,3, Anne Schraplau²

¹Department of Physical Therapy, Faculty of Medicine and Health Sciences, School of Health Professions, Tel-Aviv University, Tel-Aviv, Israel.

Therapeutic advances in neurological disorders

|August 2, 2024

概括

奇特的肌肉训练并没有改变多发性硬化症 (MS) 患者的细胞因子水平. 这一发现表明,古怪的运动对于MS康复是安全的,因为它不会引起炎症反应.

科学领域:

免疫学免疫学免疫学
运动生理学运动生理学
神经康复疗法神经康复疗法

背景情况:

奇特的肌肉收缩诱导独特的生理反应,包括细胞因子配置调节.
异常训练对多发性硬化症 (MS) 免疫系统的影响仍然未被探索.
了解这些影响对于优化MS患者康复策略至关重要.

研究的目的:

在MS患者中评估异常训练后的直接细胞因子反应 (IL-4,IL-6,IL-10,IL-17a,IFN-γ,TNF-α).
调查休息时细胞因子水平与MS患者的运动能力和下肢强度的临床测量之间的关系.
确定在MS康复中奇特运动的安全性和潜在的免疫调节作用.

主要方法:

一项观察性研究涉及27名多发性硬化症患者 (平均年龄为40.1岁).
基线细胞因子水平通过血液采样进行测量.
参与者接受了临床评估 (定时启动,5STS等). 和一个适度的奇特的运动会与运动后的细胞因子采样.

主要成果:

在基线和特异性训练后之间没有观察到细胞因子度的显著差异.
五次重复坐立测试 (5STS) 解释了干扰素- (30.3%),IL-4 (14.8%) 和IL-10 (13.8%) 水平的变异.
奇特的训练没有诱导一种促炎系统性反应.

结论:

一次奇特的运动并不会改变MS患者的血细胞因子度.
奇特的训练可以安全地纳入MS患者的康复计划.
这些发现表明,古怪的运动不会加剧MS患者的炎症.

关键词:

细胞因子反应的反应奇特的培训是奇特的培训.多发性硬化症多发性硬化症肌肉的力量肌肉的力量肌肉的力量

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