在成年人肺支气管切除症 (COS-PHyBE研究) 的物理治疗试验中开发一个核心结果集:Delphi研究和共识会议
Hayat Hamzeh1, Carol Kelly1, Annemarie L Lee2
1Faculty of Health, Social Care & Medicine, Edge Hill University, Ormskirk, UK.
Heliyon
|August 2, 2024
概括
一个核心结果集 (COS) 已开发用于支气管切除症患者的物理治疗试验. 这七个标准化结果集将提高一致性,并减少对这种疾病的临床研究中的偏见.
科学领域:
- 肺部医学 肺部医学
- 临床试验方法论 临床试验方法论
- 康复科学 康复科学 康复科学
背景情况:
- 物理治疗是支气管切除症管理的关键干预措施.
- 支持物理治疗疗效的证据是不一致的,因为在试验中报告的结果是可变的.
- 一个核心结果集 (COS) 可以标准化结果测量,提高试验可比性和减少偏差.
研究的目的:
- 开发一个基于共识的核心结果集 (COS) 进行物理治疗临床试验的成年患者与支气管病.
- 为未来的研究建立一套标准化的成果指标.
主要方法:
- 一个系统的文献审查和定性访谈确定了潜在的结果.
- 进行了一项国际双轮在线Delphi调查,涉及患者和理疗师.
- 在国际共识会议上,通过讨论和投票,最终确定了核心成果集 (COS).
主要成果:
- 最初的清单包括137个结果 (104个来自文学,33个来自采访).
- 来自20个国家的171名参与者的Delphi调查完善了这一清单.
- 他们同意七个核心结果:生活质量,呼吸系统症状,身体功能,情绪/心理功能,疲劳,治疗坚持和运动能力.
结论:
- 建议在未来对支气管切除症进行物理治疗试验时,至少设置七个核心结局.
- 实施这一COS将提高支气管切除症物理治疗研究中的证据生成的一致性和质量.
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