局部万科米辛对骨骨折手术部位感染的影响:一项随机,双盲,受控试验
Carlos A Acosta-Olivo1, Alejandro Hernández-Alejo1, Anna K Rangel-Alanís1
1Orthopedic Trauma Service, School of Medicine, Dr. José Eleuterio González" University Hospital, Universidad Autónoma de Nuevo León, Monterrey, MEX.
Cureus
|August 2, 2024
概括
局部使用的万科米辛并没有显著减少手术部位感染 (SSIs) 在接受开放脚骨折修复与内部固定的患者中. 这项研究发现,与标准抗生素预防相比,没有任何额外的益处.
科学领域:
- 整形外科手术 整形外科手术
- 预防传染病 预防传染病
- 药理学 药理学是指药理学的学科.
背景情况:
- 在高风险的手术中,局部使用万科米辛与手术部位感染 (SSI) 的减少有关.
- 它在带有内部固定的开脚手术中的有效性仍然未被评估.
研究的目的:
- 为了确定局部万科米辛是否降低SSI风险在开放的脚骨折固定.
- 在这种特殊的手术背景下评估万科米辛的预防作用.
主要方法:
- 一个随机的,双盲的,受控的试验.
- 患者接受了标准的IV血栓塞法丁或标准治疗加上局部范科米辛.
- 在手术后14天,28天和三个月监测SSI率.
主要成果:
- 范科米辛 (3.3%) 和对照组 (3.5%) 之间SSI率没有统计学上显著的差异.
- 检测到的常见病原体是金黄色葡萄球菌和宝曼菌.
- 在三个月的随访期间,两组都没有观察到任何感染.
结论:
- 局部的万科米辛在预防SSI在开放脚骨折固定方面没有明显的优势.
- 标准的预防措施似乎足够的程序.
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