与药物相关的急性病:来自世界药监数据库的数据
Alexandre Baptista1, Ana Marreiros1, Ana Macedo1
1Medicine and Biomedical Sciences, Universidade do Algarve, Faro, PRT.
Cureus
|August 2, 2024
概括
与药物相关的急性病 (AKD) 是一个常见的不良反应. 这项研究确定了许多与AKD相关的药物,包括与AKD相关的质子抑制剂,强调需要仔细评估药物.
科学领域:
- 药物监督 药物监督 药物监督
- 腎臟病學 (nephrology) 是一種醫學專業.
- 药品安全 药品安全
背景情况:
- 药物不良反应 (ADR) 经常导致毒性,特别是急性病 (AKD).
- 世界卫生组织的VigiBase数据库是识别与AKD相关药物的关键资源.
- 很大一部分AKD病例与特定药物有关.
研究的目的:
- 用药监督数据识别和评估与急性病 (AKD) 相关的药物.
- 为了对已识别的药物的毒潜力进行分类.
- 用不成比例指数评估药物和AKD之间的关联强度.
主要方法:
- 从VigiBase (1968-2022) 中检索了ADR通知.
- 使用文献评分评估药物毒性,并将药物分类为非毒性,潜在毒性或毒性.
- 利用IC025和报告几率比 (ROR) 来量化药物和AKD通知之间的关联.
主要成果:
- 分析了33,932,051份通知,确定了435677例与药物相关的AKD病例,主要是45-64岁的男性.
- 鉴定了8,991种与AKD相关的活性成分/组合;ATC类J和N很突出.
- 75%的涉及药物被归类为已知的毒药物,其中cobicistat+elvitegravir+emtricitabine+tenofovir disoproxil,inotersen和emtricitabine+tenofovir disoproxil的ROR值较高. 质子抑制剂,如埃索梅普拉和潘托普拉也经常参与其中.
结论:
- 急性病 (AKD) 是VigiBase中常见的ADR,死亡率很高.
- 药物,包括不太怀疑的药物,与AKD有很强的关联,由高不成比例指数表明.
- 这项研究强调了AKD的阳性潜力,以及考虑药物参与其发展的关键需要.
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