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Updated: Jun 18, 2025

Site-Directed Immobilization of Bone Morphogenetic Protein 2 to Solid Surfaces by Click Chemistry
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通过使用共价激酶结合元件的双价方法来增强波罗样激酶1波罗盒域结合联体的亲和力

Kohei Tsuji1,2, Hirokazu Tamamura2, Terrence R Burke1

  • 1Chemical Biology Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health Frederick MD 21702 USA burkete@mail.nih.gov.

RSC chemical biology
|August 2, 2024
PubMed
概括

研究人员开发了强大的双价抑制剂,通过将激酶域抑制剂与波罗盒域绑定剂相结合,准波罗样激酶1 (Plk1). 这些新的基于Wortmannin的配体显示出显著的Plk1亲和力,有助于用于抗癌药物开发的结构研究.

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