在癌症治疗中用于天然药物的药物输送系统
P K Hashim1,2, Naseef Punnoth Poonkuzhi3, Nusaiba Madappuram Cheruthu1,2
1Research Institute for Electronic Science, Hokkaido University, Kita 20, Nishi 10, Kita-ku, Sapporo, Hokkaido, 001-0020, Japan.
Current topics in medicinal chemistry
|August 2, 2024
概括
药物输送系统通过提高精度和最大限度地减少副作用来提高植物衍生抗癌化合物的疗效. 本综述探讨了纳米粒子和菌载体在自然癌症治疗中的进展.
科学领域:
- 药理学 药理学是指药理学的学科.
- 生物医学工程 生物医学工程
- 自然产品 化学 化学
背景情况:
- 癌症是全球主要的死亡原因,化疗是主要治疗方法.
- 合成化疗药物会引起显著的副作用,推动人们寻找替代药物.
- 草药由于其多样化的生物活性化合物提供了有前途的抗癌特性.
研究的目的:
- 审查植物衍生抗癌化合物的药物输送系统的最新进展.
- 分类和讨论有机和无机纳米粒子,脂质体和聚合物微粒的应用.
- 突出提高天然抗癌剂安全性和有效性的策略.
主要方法:
- 对抗癌症草药化合物的药物递送系统近期进展的综合文献综述.
- 药物输送载体的分类为有机和无机纳米粒子.
- 分析各种交付平台的应用,好处和挑战.
主要成果:
- 药物输送系统显著改善了草药抗癌化合物的生物可用性,受控释放和细胞吸收.
- 基于纳米粒子的载体,脂质体和聚合物微粒是有针对性的有效平台.
- 这些系统可以提高治疗效果,同时减少与常规化疗相关的副作用.
结论:
- 药物输送系统对于优化植物衍生抗癌化合物的使用至关重要.
- 需要进一步的研究,包括动物模型和临床翻译,才能充分发挥其潜力.
- 载体技术的进步有望提供更安全,更有效的自然癌症疗法.
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