儿童喘中与病毒病相关的犀牛病毒特征
Stéphanie B Lejeune1,2, Antoine Deschildre1,2, Constance L Morel1,3
1Department of Pediatric Pulmonology and Allergy, Hôpital Jeanne de Flandre, CHU Lille, Université de Lille, Lille Cedex, France.
Journal of medical virology
|August 2, 2024
概括
犀牛病毒 (RV) 病毒病常见于因严重喘发作住院的幼儿中,特别是在RV-C感染的情况下. 这一发现凸显了在喘恶化期间在血中检测RVRNA的重要性.
科学领域:
- 儿科肺病学 儿科肺病学
- 病毒学 病毒学
- 传染性疾病 传染性疾病
背景情况:
- 鼻病毒 (RV) 是儿童喘恶化的一个重要触发因素.
- 在这些事件期间,RV RNA在血中的发生和特征 (病毒性病) 并未得到充分确立.
研究的目的:
- 调查严重喘恶化学龄前儿童中犀病毒病毒病的患病率.
- 描述与病毒病相关的犀利病毒的分子类型.
主要方法:
- 一项观察性,前性,多中心研究 (VIRASTHMA2) 涉及105名住院的学龄前儿童 (1-5岁) 患有复发性喘息.
- 使用逆转录聚合酶链反应 (RT-PCR) 和RV/肠道病毒 (EV) 的分子类型分析呼吸道和血样本.
主要成果:
- 在34.3%的患有呼吸道RV/EV感染的儿童中检测到鼻病毒/肠病毒病毒症.
- 甲状病毒-C (RV-C) 是血中发现的主要类型 (82.4%),其次是肠病毒-D68 (EV-D68) 和RV-A.
- 血中确定的RV/EV类型与呼吸道样本中发现的类型一致.
结论:
- 在学龄前儿童中,风病毒/肠病毒病毒病常见于严重的喘恶化.
- 在这个人群中,RV-C感染与病毒性病特别相关,这强调了它的临床意义.
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