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与电子烟使用相关的循环细胞外微粒细胞增加了内皮细胞的炎症,减少了氧化的产生

Nicholas G Evanoff^1,2, Donald R Dengel^1,2, Kelly A Stockelman³

¹School of Kinesiology, University of Minnesota, Minneapolis, Minnesota, USA.

Experimental physiology

|August 2, 2024

概括

电子烟的使用释放出微小,增加炎症,减少内皮细胞中氧化的产生,导致心血管风险.

科学领域:

心血管生物学心血管生物学
内皮细胞生物学内皮细胞生物学
血管炎症血管炎症

背景情况:

循环的微囊泡在心血管健康和疾病中发挥着作用.
电子 (电子) 香烟使用对微粒细胞功能的影响尚不清楚.
由炎症和减少的氧化驱动的内皮功能障碍是心血管疾病的关键.

研究的目的:

调查电子烟使用者的微对人类脉内皮细胞 (HUVECs) 的影响.
评估核因子-κB (NF-κB) 激活,细胞因子释放,内皮氧化合成酶 (eNOS) 酸化和氧化 (NO) 生产的变化.

主要方法:

从非烟草使用者和慢性电子烟使用者使用流动细胞计分离了微小.
用这些分离的微囊处理了HUVEC.
测量了p-NF-κB p65的表达,总的eNOS,p-eNOS (Ser1177,Thr495) 和氧化的产生.

主要成果:

电子烟使用者的微管显著增加了互白素-6和互白素-8的释放.
在用电子烟使用者的微囊治疗的HUVEC中,NF-κB (p-NF-κB p65) 的激活率更高.
在HUVEC暴露于电子烟使用者的微囊中,eNOS在Ser1177的酸化和氧化的产生明显较低.

结论:

电子烟使用者循环的微微会促进内皮炎症.
电子烟产生的微微会损害内皮氧化的产生和活性.
这些发现表明,改变的微囊功能可能会导致与电子烟使用相关的心血管风险.

关键词:

电子烟电子烟是一种电子烟.细胞内皮细胞的内皮细胞.体内氧化合成酶的作用.这是一种炎症炎症炎症炎症.微微的微小的微小的微小的微小的微小

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