卡特 (Catha edulis) 使用对尿生殖系统的影响:系统性审查和元分析
Faisal Ahmed1, Ibrahim Alnadhari2, Saif Ghabisha1
1Ibb University of Medical Sciences, Ibb, Yemen.
Journal of ethnicity in substance abuse
|August 2, 2024
概括
怀孕期间使用卡特与低出生体重和出生缺陷有关. 卡特的消费也显著减少了男性的精液量,突出了对生殖健康的风险.
科学领域:
- 生殖健康 生殖健康
- 围产儿医学 围产儿医学
- 安德罗学与人类学
背景情况:
- 卡特 (Catha edulis) 是一种兴奋剂植物,在某些地区广泛使用.
- 人们担心它可能对人类生殖系统产生不利影响.
- 需要对现有证据进行全面审查,以了解这些风险.
研究的目的:
- 进行对调查卡特饮食对两性生殖健康影响的研究进行元分析.
- 量化卡特使用与不良妊娠结果之间的关联,包括低出生体重和先天异常.
- 评估卡特对男性生殖参数的影响,特别是精液量.
主要方法:
- 在五个主要数据库 (Embase,Medline/PubMed,Scopus,知识网络,ProQuest) 进行了系统的文献搜索,截至2024年1月.
- 包括的研究使用Joanna Briggs Institute (JBI) 批判性评估清单进行了批判性评估.
- 对10篇选定的文章进行了聚合元分析.
主要成果:
- 怀孕期间使用卡特与低出生体重 (OR=2.51) 和先天性异常 (OR=3.17) 的风险增加有显著关联.
- 查特的消费被发现可以显著降低男性的精液量 (SMD=-0.903).
- 对所有主要发现均观察到统计学意义 (p < 0.05).
结论:
- 卡特使用对生殖健康构成重大风险,怀孕不良结果和男性生育能力下降证明了这一点.
- 这些发现强调,迫切需要进一步研究卡特的生殖毒性背后的机制.
- 公共卫生倡议和临床指导应解决卡特消费对生殖健康的影响.
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