结构上多样化的stilbenoids作为强大的α-葡萄糖酶抑制剂,具有Morus alba的抗糖尿病作用
Lin-Lin Tian1, Yan-Xue Bi1, Hua Zhang1
1School of Biological Science and Technology, University of Jinan, 336 West Road of Nan Xinzhuang, Jinan 250022, China.
Journal of agricultural and food chemistry
|August 2, 2024
概括
研究人员从Morus alba中发现了五种新化合物,通过抑制α-葡萄糖酶,显示出对抗糖尿病的强大潜力. 一种化合物在小鼠中表现出显著的抗高血糖作用,与acarbose相似.
科学领域:
- 自然产品 化学 化学
- 药用化学 医学化学
- 药理学 药理学是指药理学的学科.
背景情况:
- 阿尔巴树 (Morus alba) 是生物活性化合物的来源.
- 斯蒂尔贝诺酸是一种具有多种生物活动的自然产品.
- 阿尔法-葡萄糖酶抑制剂对于管理2型糖尿病至关重要.
研究的目的:
- 从Morus alba.中分离和描述新型的stilbenoid衍生物.
- 为了评估这些化合物对α-葡萄糖酶的抑制活性.
- 评估最有前途的化合物的体内抗糖尿病疗效.
主要方法:
- 使用光谱数据 (NMR,ECD) 和计算分析进行隔离和结构阐明.
- 在体外酶抑制试验 (α-葡萄糖酶) 测定IC50值.
- 在糖尿病小鼠体内研究以评估抗高血糖活性.
主要成果:
- 确定了五种具有独特支架的新型stilbenoid衍生物 (albaphenols A-E).
- 所有分离的化合物都显示出显著的α-葡萄糖酶抑制 (0.70-8.27μM IC50).
- 在体内,Mulberrofuran G表现出强大的抗高血糖活性,与acarbose相当.
结论:
- 阿尔巴树是一种丰富的结构多样化和生物活性 stilbenoids 的来源.
- 这些新型化合物显示出作为糖尿病管理的治疗剂的有希望的潜力.
- 对Mulberrofuran G的进一步研究可能会导致新的抗糖尿病药物开发.
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