[骨肉瘤作为GES列出的病理:国家参考中心的7年经验]
Orlando Wevar Cruz1, Óscar Ceballos Diegues1, Jorge Cabrolier Jiménez1
1Oncología Ortopédica, Instituto Traumatológico, Santiago, Chile.
概括
这项关于智利骨髓瘤 (OS) 的研究发现,患者的年龄和诊断时的转移显著影响生存率. 早期检测和治疗对于改善这种骨癌的结果至关重要.
科学领域:
- 在瘤学瘤学.
- 整形外科手术 整形外科手术
- 公共卫生 公共卫生
背景情况:
- 骨髓瘤 (OS) 是最常见的原发性恶性骨瘤.
- 智利的明确健康保证 (GES) 计划在2014年包括OS,确保获得诊断,治疗和康复.
研究的目的:
- 为了表征15岁以上的智利人口被诊断患有OS.
- 为了确定生存率和并发症频率.
- 确定影响OS结果的预后因素.
主要方法:
- 智利公共卫生系统中患者的回顾性研究 (2014-2020年) 组织学证实了OS.
- 从临床记录中提取的数据包括人口统计,瘤位置,阶段,转移,治疗,并发症和存活率.
- 使用多变量分析来确定预后因素.
主要成果:
- 分析了133名患者 (58.8%是男性,平均年龄为31岁);远部大腿骨是最常见的OS部位 (34.9%).
- 56.4%的患者被诊断为恩肯 IIB 阶段; 36.4%的患者在入院时发生了转移.
- 入院时的年龄和转移是独立的预后变量 (HR为年龄1.017;转移为3.13). 非转移性患者的五年生存率为54%,转移性OS患者为11%.
结论:
- 这是智利首次对OS患者进行人口统计研究.
- 患者年龄和入院时转移的存在显著影响预后.
- 经年龄调整后,5年生存率 (73%非转移性,22%转移性) 与国际中心可比.
相关概念视频
Cancer Therapies
7.6K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
7.6K
Rous Sarcoma Virus (RSV) and Cancer
5.0K
Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
5.0K


