[1990年至2019年间智利发生的脑膜炎炎]
Darío Vergara Salazar1, Marcela Cárcamo Ibaceta2, María Teresa Valenzuela Bravo3
1Clínica BUPA Reñaca, Viña del Mar, Chile.
Andes pediatrica : revista Chilena de pediatria
|August 2, 2024
概括
智利的Neisseria meningitidis爆发显示了血清组的转变,W血清组变得越来越普遍. 2012年的这一变化导致脑膜炎病例减少,但脑膜炎球菌病和侵入性脑膜炎球菌病 (IMD) 死亡率增加.
科学领域:
- 流行病学 流行病学
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 自1941年以来,智利发生了尼塞利亚脑膜炎的爆发,临床表现,发病率和血清组流行率各不相同.
- 了解Neisseria meningitidis的流行病学概况对于公共卫生干预至关重要.
研究的目的:
- 总结关于智利Neisseria meningitidis引起的急性细菌脑膜炎的流行病学概况的证据.
- 分析1990年至2019年间尼塞利亚脑膜炎脑膜炎的发生率.
主要方法:
- 根据Cochrane协作标准,对主要文章进行了系统的审查.
- 数据来源包括PubMed,Scielo和LILACS,重点是英语和西班牙语的Neisseria meningitidis脑膜炎描述性研究.
- 排除了关于疫苗有效性和诊断技术的研究.
主要成果:
- 1990-2019年间的证据集中在2012年,报告了133例侵入性脑膜炎球菌病 (IMD),其中42例是脑膜炎.
- 血清组W135菌株导致脑膜炎的IMD病例占21.7%,而非W135菌株占67.4%.
- 与非W135 (13.9%) 相比,由W135血清组引起的IMD的死亡率更高 (26.7%).
结论:
- 2012年标志着流行血清组从B转向W的转变.
- 这种血清组变化与脑膜炎病例的减少有关,但脑膜炎球菌病和IMD总体致死率的增加.
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