与COVID-19疫苗接种相关的心膜炎:一项韩国全国性的研究
Nuri Lee1, Kye Hun Kim2, Jae-Hyeong Park3
1Department of Cardiovascular Medicine, Chonnam National University Hospital, Gwangju, Korea; Department of Cardiovascular Medicine, Chonnam National University Hwasun Hospital, Hwasun, Jeollanam-do, Korea.
Mayo Clinic proceedings
|August 2, 2024
概括
与COVID-19疫苗相关的心膜炎 (VRP) 是罕见的,主要影响接受mRNA疫苗的40岁以下男性. 虽然通常是温和的,没有死亡,但显著的心周溢出需要监测.
科学领域:
- 心脏病学 心脏病学
- 疫苗学 疫苗学 疫苗学
- 公共卫生 公共卫生
背景情况:
- 心周炎是心周的炎症,心周围包围心脏.
- COVID-19疫苗与罕见的不良事件有关,包括心肌炎和心周炎.
- 了解没有心肌炎的疫苗相关心膜炎 (VRP) 对于疫苗安全监测至关重要.
研究的目的:
- 为了确定在韩国没有心肌炎的COVID-19疫苗相关心膜炎 (VRP) 的发病率.
- 描述VRP的临床特征和结果.
- 为了确定VRP的人口和疫苗特异性风险因素.
主要方法:
- 在韩国对接种COVID-19疫苗的个人进行了回顾性全国性分析 (2021年2月至12月).
- 包括所有疫苗平台:BNT162b2,mRNA-1273,ChAdOx1,Ad26.COV2.S. 在其中.
- 由专家委员会裁决的VRP确诊病例;发生率,特征和结果的分析.
主要成果:
- 在44 322 068名接种疫苗的人群中发现了179例VRP病例 (每百万剂量为1.73).
- 在男性 (2.01/百万),mRNA疫苗 (2.09/百万) 和40岁以下 (3.52/百万) 个体中,VRP发病率较高.
- 在12-17岁的男性中发生率最高 (7.38 / 百万);5.6%出现显著的心周溢出,没有死亡率.
结论:
- COVID-19 VRP是一种罕见的不良事件,主要与年轻男性的mRNA疫苗有关.
- VRP的临床过程通常是有利的,没有报告的死亡.
- 建议密切监测血液动力学上显著的心周输液.
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