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针对乳腺癌的抗体-药物联合体:一项文献计量研究和临床试验分析

Mengjie Xing¹, Zhiyi Li², Yuwan Cui²

¹Department of Clinical Laboratory, First Bethune Hospital of Jilin University, Changchun, China.

Discover oncology

|August 2, 2024

概括

抗体-药物结合物 (ADC) 正在彻底改变乳腺癌的治疗方法. 本研究分析了研究趋势和临床试验,突出了ADCs.

科学领域:

在瘤学瘤学.
药理学药理学是指药理学的学科.
生物技术是生物技术.

背景情况:

乳腺癌 (BC) 是女性癌症相关死亡的主要原因,特别是在晚期.
对转移性BC的有效治疗干预措施是有限的.
抗体-药物结合物 (ADC) 提供针对BC的向治疗,特别是 HER2-过度表达的亚型.

研究的目的:

综合关于乳腺癌中ADCs的初级研究成果.
阐明当前的研究环境,并确定未来的创新途径.
分析图书统计数据和临床试验信息.

主要方法:

在乳腺癌中的2181个ADC条目的图书统计分析来自Web of Science (1999-2023).
使用CiteSpace和VOSviewer进行出版趋势,国家贡献和爆发分析.
选了来自ClinicalTrials.gov和WHO ICTRP的119项临床试验,用于ADC治疗策略.

主要成果:

对乳腺癌中ADC的研究表明,这一趋势在不断增长.
美国 (36.56%) 和中国 (21.33%) 是主要的贡献者.
分子生物学,免疫学和遗传学的进步,以及NMR诊断,支持ADC的发展.

结论:

14种ADC被FDA批准,显著改善了临床结果.
未来的研究应该探索向突变的coproteins,双重特异性的ADCs,以及新的结合策略.
针对性癌症治疗中,ADCs具有变革性的潜力.

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