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Updated: Jun 18, 2025

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由CAR-T细胞表达的互白素-7改善了CAR-T细胞的存活率和在胆瘤中的疗效

Huantong Wu1,2, Zhuofan Xu1,2, Maoyang Qi1,2

  • 1Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China.

Cancer immunology, immunotherapy : CII
|August 2, 2024
PubMed
概括

这项研究确定了B7-H3作为标,IL-7作为瘤免疫疗法的强化剂. 将B7-H3向的化学抗原受体T (CAR-T) 细胞与IL-7结合起来,显示出增强的抗瘤活性.

关键词:
B7H3 B7H3 B7H3 B7H3 B7H3 B7H3 B7H3 B7H3化学抗原受体 T 细胞一个叫做chordoma的小组.介质素-7- 介质素-7 是一种

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
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