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The JAK-STAT Signaling Pathway01:20

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Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as  SH2...
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The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
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Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
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[系统性硬化症的最新情况]

Gabriela Riemekasten1, Ulf Müller-Ladner2

  • 1Klinik für Rheumatologie und Klinische Immunologie, Universitätsklinikum Schleswig-Holstein Campus Lübeck, Forschungszentrum Borstel, Universität zu Lübeck, Ratzeburger Allee 160, 23538, Lübeck Deutschland, Deutschland. gabriela.riemekasten@uksh.de.

Zeitschrift fur Rheumatologie
|August 2, 2024
PubMed
概括

最近的研究推进了系统性硬化症 (SSc) 的理解,为病原和治疗提供了新的见解. 这份概述补充了目前的指导方针,提供了有关SSc管理的实用信息.

关键词:
心脏的参与心脏的参与.胃肠道的参与 胃肠道的参与准则 准则 准则 准则建议 建议 建议治疗方法 治疗方法

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科学领域:

  • 类风湿病学 类风湿病学
  • 免疫学 免疫学 免疫学
  • 内部医学 内部医学

背景情况:

  • 系统性硬化症 (SSc) 治疗的欧洲和德国指南即将公布.
  • 现有的指导方针可能不涵盖在文献审查后发表的最新发现.
  • 需要更新有关SSc表现和治疗的信息.

研究的目的:

  • 审查与系统性硬化症相关的最近出版物 (去年).
  • 提供实用,最新的信息来补充现有指南.
  • 突出SSc病变发生,表现和治疗方面的关键发现.

主要方法:

  • 对过去一年的出版物进行文献综述.
  • 专注于与临床实践和指南补充相关的研究.
  • 综合SSc病变发生,心脏和肺部参与以及治疗选择的发现.

主要成果:

  • 更好地了解SSc的病原性,包括环境因素和自身抗体.
  • 对心脏参与和SSc.预后的新见解.
  • 美国胸腔学会发布的SSc治疗间歇性肺病的第一份指导方针.
  • 证据支持像rituximab和mycophenolate mofetil (MMF) 这样的组合疗法.
  • 发炎变化被确定为常见的联合参与.
  • 介绍了胃肠道表现现的当前治疗选择.

结论:

  • 系统性硬化症的诊断和治疗正在进步.
  • 许多SSc症状和并发症正在变得可治疗.
  • 需要进一步的研究来提高患者的生活质量.