空气污染和类风湿性关节炎风险和进展:对粘膜起源假设和气候变化对RA病变发生的影响
Katarina J Bade1, Kevin T Mueller1, Jeffrey A Sparks2,3
1Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital, 60 Fenwood Road, #6016U, Boston, MA, 02115, USA.
Current rheumatology reports
|August 2, 2024
概括
空气污染,包括颗粒物 (PM2.5),与患类风湿性关节炎 (RA),特别是血清阳性RA的风险更高有关. 随着污染水平的上升,气候变化可能会加剧这种风险.
科学领域:
- 环境健康 环境健康
- 类风湿病学 类风湿病学
- 流行病学 流行病学
背景情况:
- 类风湿性关节炎 (RA) 是一种慢性自身免疫性疾病,发病率越来越高.
- 环境因素,包括空气污染,被怀疑是导致RA发展的因素.
- 了解空气质量和RA之间的联系对于公众健康至关重要.
研究的目的:
- 审查和综合当前关于空气污染与类风湿性关节炎 (RA) 风险和进展之间的联系的研究.
- 为了确定涉及RA发展的特定空气污染物.
- 探索空气污染对RA疾病活动和相关疾病的影响.
主要方法:
- 对现有流行病学研究进行系统审查.
- 对研究各种空气污染物的研究进行分析,例如颗粒物 (PM2.5,PM10),CO,NO2,NOx,SO2和O3.
- 审查有关职业暴露及其与RA的关系的研究.
主要成果:
- 对空气污染物的暴露增加与发展RA,特别是血清阳性RA的更高风险有关.
- 有证据表明,血清阳性RA风险的基因环境相互作用.
- 关于空气污染对RA疾病活动和骨质侵蚀的影响的研究有限;然而,一些研究表明RA-ILD患者暴露于污染物的结果更差.
结论:
- 空气污染在病毒阳性RA的发展中起着重要作用.
- 空气污染水平的上升,可能是气候变化造成的,可能会导致RA发病率的增加.
- 需要进一步的研究,以充分阐明空气污染对RA进展和疾病活动的影响.
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