在患有高级非小细胞肺癌和肥胖症的患者中,免疫疗法和整体生存率
Yasutaka Ihara1, Kenji Sawa2, Takumi Imai1
1Department of Medical Statistics, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan.
JAMA network open
|August 2, 2024
概括
肥胖影响癌症治疗结果. 与传统化疗相比,免疫检查点抑制剂治疗可能不会改善超重或肥胖患者的存活率,这些患者患有晚期非小细胞肺癌.
科学领域:
- 在瘤学瘤学.
- 免疫治疗是一种免疫疗法.
- 癌症研究 癌症研究
背景情况:
- 肥胖与癌症治疗反应 (包括免疫疗法) 之间的关系尚不清楚.
- 相互矛盾的研究结果凸显了对肥胖癌症患者的最佳第一线治疗需要明确的需要.
研究的目的:
- 确定身体质量指数 (BMI) 是否影响免疫疗法与常规化疗在晚期非小细胞肺癌 (aNSCLC) 的有效性.
主要方法:
- 日本31,257名aNSCLC患者 (2015-2023) 的回顾性队列研究.
- 在接受免疫检查点抑制剂 (ICI) 治疗的患者和接受常规化疗的患者之间比较整体生存率.
- 根据身体质量指数 (BMI) 类别分析的数据.
主要成果:
- 与常规化疗相比,ICI治疗与BMI<28的患者的死亡风险显著降低.
- 在BMI≥28的患者中,没有观察到ICI治疗对生存的显著益处.
- 超重或肥胖 (BMI ≥28) 的患者在ICI治疗与常规化疗相比没有改善存活率.
结论:
- 身体质量指数改变了ICI治疗与常规化疗治疗的高级非小细胞肺癌患者的生存结果.
- 免疫检查点抑制剂治疗可能不是超重或肥胖的aNSCLC患者的最佳第一线治疗.
- 应该考虑传统化疗作为超重或肥胖的NSCLC患者的潜在一线治疗选择.
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