在患有严重创伤性脏损伤的患者中,手术修复与脏切除
Dominik A Jakob1,2,3, Martin Müller2, Apostolos Kolitsas1
1Division of Trauma and Surgical Critical Care, Department of Surgery, Los Angeles General Medical Center, University of Southern California, Los Angeles.
JAMA network open
|August 2, 2024
概括
在患有严重创伤性骨损伤的患者中,手术修复骨与与骨切除术相比,医院内死亡率明显降低. 保存脏可能会改善选择性创伤病例的结果.
科学领域:
- 创伤外科 手术 创伤外科
- 外科手术的结果
- 紧急医疗 紧急医疗
背景情况:
- 在腹腔切除过程中创伤性腹部损伤后,脏切除 (脊髓切除术) 是常见的.
- 在这种情况下,通常会做出有限的努力来保护脏.
- 手术管理对创伤性骨损伤的结果的影响尚未完全理解.
研究的目的:
- 调查手术管理 (脏修复与切除术) 与患者治疗结果之间的关联.
- 为了确定脊髓修复是否与相比脊髓切除术在创伤性脊髓损伤中的死亡率降低有关.
主要方法:
- 使用美国外科医生学院创伤质量改善计划数据库 (2013-2019) 的回顾性队列研究.
- 包括严重脏损伤的成年患者 (简称损伤量表3-5级),在入院6小时内接受腹腔切除术.
- 统计分析包括:1:1精确匹配与条件后勤回归,多变量后勤回归,倾向得分匹配和反向概率加权.
主要成果:
- 总共有11,247名患有严重创伤性骨损伤的患者被分析;96.2%接受了切除术,3.8%接受了骨修复.
- 在匹配的队列中,脏修复组 (6.5%) 的死亡率明显低于脏切除组 (12.8%).
- 脏修复独立地与较低的住院死亡率相关 (调整后几率比,0.4;95% CI,0.2-0.9;P=.03).
结论:
- 由于严重的创伤性脏损伤而进行腹腔切除术期间的脏修复与脏切除术相比,独立地与死亡率降低有关.
- 这些发现表明,在严重的脏创伤的特定情况下,脏保护的努力可能是有益的.
- 进一步的研究和临床考虑脏救援程序是有必要的.
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