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比梅基祖马布在斑块性牛皮的安全性:一个专家共识小组

Joshua Burshtein, Milaan Shah, Danny Zakria

Journal of drugs in dermatology : JDD

|August 2, 2024

概括

比梅基祖马布 (Bimekizumab) 是一种用于斑块性牛皮的新生物药物,其安全性与其他治疗方法相似,口腔候群病风险显著增加. 专家的共识支持其用于中度至重度病例.

科学领域:

皮肤病学皮肤病学
免疫学免疫学免疫学
药理学药理学是指药理学的学科.

背景情况:

斑块牛皮是一种慢性系统性疾病,影响生活质量.
比梅基祖马布针对IL-17A和IL-17F,获得FDA批准用于中度至严重的斑块牛皮.
对比梅奇祖马布的安全指南对于临床实践至关重要.

研究的目的:

建立共识陈述和建议,关于bimikizumab对于斑块性牛皮的安全性.
提供专家指导,对bimequizumab的临床使用.

主要方法:

在PubMed,Scopus和谷歌学者中进行了全面的文献搜索.
一个由皮肤科医生和风湿病学家组成的小组审查了相关文章.
共识声明是使用修改后的Delphi流程和强度推标准开发的.

主要成果:

从最初的搜索110.0中确定了15个相关的文章.
专家小组一致通过了5份共识声明和建议.
所有建议都获得了"A"强度的建议.

结论:

比梅基祖马布的安全性与其他生物药物一致,具有增加口腔候群病的风险.
肝脏安全性与FDA批准的其他用于斑块牛皮的生物药物相当.
没有发现与自杀的相关性,并且炎症性肠病的发病率与其他IL-17抑制剂相似.

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