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评估Cy-Tb对印度LTBI的成本效益:全面的经济建模分析

Malaisamy Muniyandi¹, Karikalan Nagarajan¹, Kavi Mathiyazhagan¹

¹Indian Council of Medical Research-National Institute for Research in Tuberculosis, Chennai, India.

International health

|August 2, 2024

概括

Cy-Tb测试是诊断潜在结核病感染 (LTBI) 的一个具有成本效益的工具,通过结核病预防疗法 (TPT) 预防结核病病例. 降低其成本可以使其成为一个节省成本的战略.

科学领域:

公共卫生公共卫生
卫生经济学卫生经济学
传染病诊断传染病诊断传染病诊断

背景情况:

潜在结核感染 (LTBI) 诊断缺乏黄金标准,目前的干扰素γ释放试验 (IGRA) 和结核素皮肤试验 (TST) 等方法显示出局限性.
现有的LTBI诊断试验的敏感性不足,特别是具有低细菌负担的诊断试验,需要提高诊断准确性.
开发特定和准确的诊断测试对于有效的LTBI识别和管理至关重要.

研究的目的:

估计Cy-Tb测试与用于诊断LTBI的TST相比的成本效益.
评估通过使用Cy-Tb测试与结核病预防疗法 (TPT) 预防结核病病例的增量成本和数量.

主要方法:

从卫生系统的角度使用决策树分析进行经济建模研究.
从已发表的文献中收集有关人口统计,治疗结果和TST和Cy-Tb测试成本的二次数据.
计算增量成本效益比率 (ICER) 和评估不确定性,使用敏感性分析.

主要成果:

诊断一个LTBI病例和预防一个TB病例需要额外花费约223.5美元,使用TPT的Cy-Tb测试来预防一个TB病例.
概率学敏感性分析证实,Cy-Tb测试与LTBI诊断的TST相比,具有成本效益.
降低Cy-Tb测试的成本可以将其转化为节省成本的诊断策略.

结论:

在目前的价格点上,Cy-Tb测试证明了LTBI诊断的成本效益.
价格谈判和大量采购Cy-Tb测试可以提高其经济效益,可能使其成为一个节省成本的干预措施.
医疗保健提供者和政策制定者应该考虑实施Cy-Tb测试,以优化结核病控制计划的经济结果.

关键词:

这就是Cy-Tbb.控制结核病控制结核病分析成本效益分析.诊断工具诊断工具诊断工具潜伏的结核病感染.结核素皮肤试验

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