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Updated: Jun 18, 2025

Author Spotlight: Characterizing DNA G-Quadruplex by Bis-3-Chloropiperidine Based Chemical Mapping
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Author Spotlight: Characterizing DNA G-Quadruplex by Bis-3-Chloropiperidine Based Chemical Mapping

Published on: May 12, 2023

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通过DNA四重复-双重复结构增强识别一种草药化合物epiberberine

Xuan Zhan1, Liping Deng1, Yun Lian1

  • 1School of Medicine, The Chinese University of Hong Kong, Shenzhen (CUHK-Shenzhen), Shenzhen 518172, Guangdong, P. R. China.

Analytical chemistry
|August 2, 2024
PubMed
概括

乙柏林 (EPI) 结合人类端粒G四重复 (HTG) DNA,稳定其结构. 工程DNA序列增强了EPI结合亲和力,并使其从天然提取物中净化.

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DNA Base Pairing02:27

DNA Base Pairing

Erwin Chargaff’s rules on DNA equivalence paved the way for the discovery of base pairing in DNA. Chargaff’s rules state that in a double-stranded DNA molecule,
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Since the discovery of the two BER pathways, there has been a debate about how a cell chooses one pathway over the other and the factors determining this selection. Numerous in vitro experiments have pointed out multiple determinants for the sub-pathway selection. These are:
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