EAT-Lancet参考饮食与代谢功能障碍相关的脂肪性肝病及其严重程度的关联:一个多队列研究
Shunming Zhang1, Yan Yan2, Xu-Fen Zeng3
1School of Public Health, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi, China.
Hepatology (Baltimore, Md.)
|August 2, 2024
概括
坚持EAT-Lancet饮食可能会降低与代谢功能障碍相关的脂肪性肝病 (MASLD) 的风险和严重程度. 这种全球饮食模式显示出对肝脏健康的前景.
科学领域:
- 营养科学 营养科学
- 肝病学 肝病学是一种肝病学.
- 公共卫生 公共卫生
背景情况:
- EAT-Lancet委员会提出了一种可持续的饮食,对健康和环境都有好处.
- EAT-Lancet饮食对代谢功能障碍相关的脂肪性肝病 (MASLD) 的影响仍未得到研究.
- MASLD是一个日益严重的全球健康问题,具有重大影响.
研究的目的:
- 评估遵守EAT-Lancet饮食和患MASLD的风险之间的关联.
- 调查EAT-Lancet饮食和MASLD的严重程度之间的关系.
- 评估EAT-Lancet饮食在管理肝脏健康方面的潜在作用.
主要方法:
- 一项前性多队列研究,涉及来自TCLSIH,GNHS和英国生物库队列的19万多名成年人.
- 开发EAT-Lancet饮食指数,以量化遵守参考饮食的情况.
- 从PERSONS队列中包括了经过活检证明的MASLD病例,以使用肝控制的减弱参数来评估疾病严重程度.
主要成果:
- 对EAT-Lancet饮食的更高坚持与所有三个队列中MASLD风险较低显著相关.
- 参与者在EAT-Lancet饮食指数中最高的三位数中显示,MASLD风险降低 (例如,英国生物银行:HR = 0.73).
- 在活检证明的MASLD患者中,增加对EAT-Lancet饮食的坚持与肝控制衰减参数的降低相关,表明严重程度降低.
结论:
- 坚持EAT-Lancet参考饮食与MASLD的风险和严重程度相反相关.
- EAT-Lancet饮食可以作为一种有益的饮食策略,用于预防和管理MASLD.
- 这些发现凸显了可持续饮食模式在解决非传染性肝病方面的潜力.
相关概念视频
01:24Overview of Lipid Metabolism
1.3K
Lipid metabolism is a crucial process in the human body that involves the synthesis and degradation of lipids. This process is essential for energy production, cell membrane formation, and hormone production, among other functions.
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
1.3K
01:30Liver Physiology
477
The liver, an essential organ in the human body, performs over 200 vital functions that can be broadly categorized into metabolic, hematological, endocrine regulation, and bile production.
Metabolic Regulation:
The liver is the central organ involved in regulating blood composition. It stabilizes blood glucose levels, maintaining them within the range of 70–110 mg/dL. When these levels drop, the liver breaks down glycogen reserves and releases glucose into the bloodstream. It can...
Metabolic Regulation:
The liver is the central organ involved in regulating blood composition. It stabilizes blood glucose levels, maintaining them within the range of 70–110 mg/dL. When these levels drop, the liver breaks down glycogen reserves and releases glucose into the bloodstream. It can...
477
01:26Diseases of the Liver and Gallbladder
499
Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...
499