静脉输入Ondansetron化物和纳夫西林的物理兼容性
Christina Beran1, Mitchell S Howard1, Gabriella Baki1
1University of Toledo College of Pharmacy and Pharmaceutical Sciences, Toledo, Ohio.
高度的丹塞二化物 (2毫克/毫升) 与纳夫西林 (20毫克/毫升) 在物理上不兼容. 较低度 (0.16毫克/毫升) 可能与较短的持续时间相容,但建议在长时间的静脉注射同时使用时谨慎使用.
科学领域:
- 制药科学 制药科学
- 临床药房 临床药房
- 在体外药物兼容性研究中.
背景情况:
- 静脉注射 (IV) 药物的物理兼容性对于急性护理中的患者安全至关重要.
- 现有的药物信息资源缺乏关于丹塞的玻尿酸度的数据,需要进一步调查.
研究的目的:
- 为了研究体外的物理兼容性ondansetron化与纳夫西林在玻尿酸和输液度.
- 评估不同度对随时间变化的添加剂稳定性的影响.
主要方法:
- 两种不同度的 (2 mg/mL和0.16 mg/mL的ondansetron) 的ondansetron化水和纳夫西林混合物被制备了三倍.
- 添加剂在室温下储存24小时,并在多个时间点评估视觉降水,度和pH值.
主要成果:
- 添加剂与高度昂丹塞化 (2毫克/毫升) 和纳夫西林 (20毫克/毫升) 的混合物显示出立即的雾和持续的不稳定性.
- 添加剂中含有较低度的丹塞龙化物 (0.16 mg/mL) 和纳夫西林 (20 mg/mL) 的混合物在5小时后产生雾,pH值稳定,吸收度持续至24小时.
结论:
- 2毫克/毫升的Ondansetron化物在物理上与20毫克/毫升的纳夫西林不兼容,用于静脉注射.
- 由于潜在的不相容性,同时给IV注射丹塞龙化物0.16 mg/mL和纳夫西林20 mg/mL的持续时间超过5小时是有问题的.
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