在精英运动员中对COVID-19疫苗接种的免疫反应
Lea Halmans1, Andreas Venhorst1, Verena Klemis2
1Saarland University, Department of Sports Medicine, Saarbrücken, Germany.
Exercise immunology review
|August 2, 2024
概括
精英运动员对mRNA和载体COVID-19疫苗表现出明显的免疫反应. 异质mRNA增强剂在单次载体疫苗剂量后显著增强了免疫标记物,具有轻微的副作用.
科学领域:
- 免疫学 免疫学 免疫学
- 疫苗学 疫苗学 疫苗学
- 运动医学 运动医学
背景情况:
- 了解精英运动员对COVID-19疫苗的免疫反应对于保持表现和健康至关重要.
- 不同的疫苗平台 (mRNA和病毒载体) 可能会引起不同的免疫性和反应性特征.
研究的目的:
- 分析和比较不同的COVID-19疫苗接种方案的精英运动员的免疫反应,包括抗体标位,中和活性和T细胞概况.
- 评估异质增强剂对先前用单剂量载体疫苗接种过的运动员免疫反应的影响.
主要方法:
- 从72名精英运动员的血液样本中分析了免疫球蛋白G (IgG) 抗体标位,中和活性和CD4/CD8 T细胞反应.
- 运动员接受了双剂量mRNA疫苗 (BNT162b2 / mRNA-1273) 或单剂量载体疫苗 (Ad26.COV.2).
- 对于每种疫苗接种方案,都记录了副作用和训练时间损失.
主要成果:
- 与单剂量载体疫苗相比,双剂量mRNA疫苗引发了显著更高的IgG抗体标位,中和活性和CD4 T细胞反应.
- 与mRNA疫苗相比,单剂量载体疫苗导致了较高的SARS-CoV-2尖端特异性CD8T细胞水平.
- 用mRNA疫苗对载体疫苗接种的运动员进行异质增强导致IgG抗体,中和活性以及CD4和CD8T细胞反应的显著增加.
结论:
- mRNA和载体COVID-19疫苗在精英运动员中诱导了不同的免疫反应模式.
- 单剂量载体疫苗的较低免疫性可以通过随后的异质mRNA增强剂有效地优化.
- 接种疫苗的反应一般是轻微的和短暂的,在治疗方案之间累积的训练时间损失没有显著差异.
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