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开发用于癌症治疗的体内CAR T细胞疗法的进展和挑战

Thuy Anh Bui¹, Haoqi Mei², Rui Sang³

¹School of Biomedical Engineering, University of Technology Sydney, Ultimo, NSW 2007, Australia; Whitlam Orthopaedic Research Centre, Ingham Institute for Applied Medical Research, Liverpool, NSW 2170, Australia; School of Clinical Medicine, Faculty of Medicine, University of New South Wales Sydney, Kensington, NSW 2052, Australia.

|August 2, 2024

概括

在体内化学抗原受体 (CAR) T 细胞疗法为癌症治疗提供了与体外疗法相比具有成本效益的替代方案. 本综述探讨了直接在体内产生CAR T细胞的进步和挑战.

科学领域:

免疫治疗是一种免疫疗法.
在瘤学瘤学.
生物技术是生物技术.

背景情况:

化学抗原受体 (CAR) T细胞疗法是一种革命性的癌症治疗方法.
目前的ex vivoCAR T细胞生产是复杂而昂贵的.
现场CAR T细胞生成旨在简化和降低成本.

研究的目的:

审查最近在T细胞向的CAR生成现场的进展.
确定与体内CAR T细胞治疗相关的挑战.
提出克服这些挑战的策略.

主要方法:

对用于CAR基因传递的工程纳米载体的审查.
对病毒载体进行分析,以在现场生成CAR T细胞.
探索T细胞特异性向策略.

主要成果:

在开发现场CAR T细胞生成技术方面取得了重大进展.
工程化纳米载体和病毒载体显示出在体内基因传递的前景.
针对T细胞的特定向对于有效的局部CAR T细胞治疗至关重要.

结论:

活体中CAR T细胞生成为外体方法提供了一个可行的替代方案.
克服制造复杂性和成本是一个关键优势.
需要进一步的研究来应对挑战,并优化体内CAR T细胞疗法以获得广泛的临床应用.

关键词:

癌症癌症癌症癌症基因输送基因输送基因输送基因编辑基因编辑在活体中,CAR-T

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