前列腺癌患者的PSA水平和死亡率
Dietrich von Kuenssberg Jehle1, Nam Nguyen1, Michael A Garza1
1Department of Emergency Medicine, University of Texas Medical Branch, Galveston, TX.
Clinical genitourinary cancer
|August 2, 2024
概括
前列腺癌 (PC) 查抗原 (PSA) 水平升高与死亡率增加相关. 黑人男性PC和PSA水平≥20显示2年死亡率低于白人男性.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 在瘤学瘤学.
- 流行病学 流行病学
背景情况:
- 前列腺癌 (PC) 是全球男性的主要癌症.
- 关于前列腺特异性抗原 (PSA) 水平与前列腺癌死亡率之间的关联,存在相互矛盾的数据.
- 黑人男性在晚期阶段面临更高的PC诊断率和增加的死亡风险.
研究的目的:
- 为了研究PSA水平和PC患者的死亡率之间的关系.
- 分析黑人和白人患者PC死亡率的种族差异.
主要方法:
- 从TriNetX数据库中对198,083个被删除的EMR进行了回顾性分析.
- 包括在诊断前6个月内被诊断出PC和PSA水平的患者.
- 队列根据PSA水平 (<2到≥500 ng/mL) 分层,并与对照 (4-20 ng/mL) 进行2年死亡率的比较;子组分析检查了种族差异和5年和10年死亡率.
主要成果:
- 对于PSA<2 ng/mL (5.9%对比7.5%) 观察到较低的死亡风险.
- 在PSA水平>20 ng/mL时,发现死亡风险较高,最高水平为200-500 ng/mL (50.4%对10.8%).
- 与白人患者相比,PSA≥20 ng/mL的黑人患者的2年死亡率明显较低.
结论:
- 在PC患者中PSA水平显著升高与死亡率增加有关.
- 具有PC和PSA水平≥20ng/mL的黑人患者的2年死亡率低于白人患者.
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