Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Evolutionary Relationships through Genome Comparisons02:54

Evolutionary Relationships through Genome Comparisons

5.7K
Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...
5.7K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

The genetic signature of memory encoding along the human hippocampal axis.

bioRxiv : the preprint server for biology·2026
Same author

Comparative analysis of the cellular landscape in mammalian striatum.

Nature communications·2026
Same author

Combined somatic mutation and transcriptome analysis reveals region-specific differences in clonal architecture in human cortex.

Cell reports·2025
Same author

Resilience to Endoplasmic Reticulum Stress Mitigates Membrane Hyperexcitability Underlying Late Disease Onset in a Murine Model of SCA6.

Annals of neurology·2025
Same author

Buried Treasure? Overlooked and Newly Discovered Evolutionary Contributions to Human Brain Diseases.

Annals of neurology·2025
Same author

Decoding DNA sequence-driven evolution of the human brain epigenome at cellular resolution.

Nature communications·2025

相关实验视频

Updated: Jun 18, 2025

Single-cell RNA-Seq of Defined Subsets of Retinal Ganglion Cells
11:26

Single-cell RNA-Seq of Defined Subsets of Retinal Ganglion Cells

Published on: May 22, 2017

13.8K

在单细胞分辨率上的进化神经基因组学.

Emre Caglayan1, Genevieve Konopka1

  • 1Department of Neuroscience, Peter O'Donnell Jr. Brain Institute, UT Southwestern Medical Center, Dallas, TX 75390, USA.

Current opinion in genetics & development
|August 2, 2024
PubMed
概括

单细胞基因组学揭示了脑细胞的多样性和物种间的进化变化. 这篇综述强调了人类特异性基因组创新和对比脑研究的未来研究方向.

科学领域:

  • 神经科学是一个神经科学.
  • 基因组学就是基因组学.
  • 进化生物学 进化生物学

背景情况:

  • 人类大脑包括多样化的细胞类型,单细胞基因组学提供了对它们的比例和基因调节的见解.
  • 在单细胞分辨率下,跨物种的比较基因组学对于理解大脑进化至关重要.

研究的目的:

  • 审查使用高通量基因组学的最新研究,以在单细胞分辨率下比较物种间的大脑.
  • 识别和讨论与人类相关的大脑进化创新.
  • 突出比较单细胞基因组学中尚未探索的领域.

主要方法:

  • 对大脑组织的高通量基因组学研究的审查.
  • 分析单细胞数据,进行物种间比较.
  • 专注于差异性基因表达和调节.

主要成果:

  • 在物种中识别保存和新型基因组元素.
  • 在大脑中发现人类特异性基因组创新.
  • 阐明细胞类型比例和基因表达模式.

结论:

  • 单细胞基因组学为比较大脑研究提供了一个强大的镜头.

更多相关视频

Single-cell RNA Sequencing of Fluorescently Labeled Mouse Neurons Using Manual Sorting and Double In Vitro Transcription with Absolute Counts Sequencing DIVA-Seq
07:49

Single-cell RNA Sequencing of Fluorescently Labeled Mouse Neurons Using Manual Sorting and Double In Vitro Transcription with Absolute Counts Sequencing DIVA-Seq

Published on: October 26, 2018

9.5K
Nuclei Isolation from Fresh Frozen Brain Tumors for Single-Nucleus RNA-seq and ATAC-seq
06:22

Nuclei Isolation from Fresh Frozen Brain Tumors for Single-Nucleus RNA-seq and ATAC-seq

Published on: August 25, 2020

12.2K

相关实验视频

Last Updated: Jun 18, 2025

Single-cell RNA-Seq of Defined Subsets of Retinal Ganglion Cells
11:26

Single-cell RNA-Seq of Defined Subsets of Retinal Ganglion Cells

Published on: May 22, 2017

13.8K
Single-cell RNA Sequencing of Fluorescently Labeled Mouse Neurons Using Manual Sorting and Double In Vitro Transcription with Absolute Counts Sequencing DIVA-Seq
07:49

Single-cell RNA Sequencing of Fluorescently Labeled Mouse Neurons Using Manual Sorting and Double In Vitro Transcription with Absolute Counts Sequencing DIVA-Seq

Published on: October 26, 2018

9.5K
Nuclei Isolation from Fresh Frozen Brain Tumors for Single-Nucleus RNA-seq and ATAC-seq
06:22

Nuclei Isolation from Fresh Frozen Brain Tumors for Single-Nucleus RNA-seq and ATAC-seq

Published on: August 25, 2020

12.2K
  • 人类特异性基因组变化为独特的认知能力提供了洞察力.
  • 技术和生物学限制需要在比较神经基因组学中进一步探索.