在旋转下基乙基甲酸盐 (HEMA) 的聚合,形成核心环状的水凝
Zachary Sparks1, Anuj Chauhan1
1Department of Chemical and Biological Engineering, Colorado School of Mines, Golden, CO 80401, United States.
Journal of colloid and interface science
|August 2, 2024
概括
基乙基甲酸盐 (HEMA) 水凝的旋转筒聚合制造出多孔结构,影响蛋白质扩散. 较高的水含量产生具有相互连接的毛孔的同otropic 凝,增强蛋白质的运输.
科学领域:
- 生物材料科学 生物材料科学
- 聚合物化学 聚合物化学
- 药物输送系统 药物输送系统
背景情况:
- 基乙基甲酸盐 (HEMA) 水凝是广泛使用的生物材料.
- 控制水凝微结构对于药物输送等应用至关重要.
- 在多孔水凝中的蛋白质运输受结构性质的影响.
研究的目的:
- 为了研究旋转聚合物对高含水量HEMA水凝微结构的影响.
- 为了确定旋转如何影响由此产生的多孔多HEMA凝中的蛋白质扩散性.
- 为了将凝微结构与蛋白质运输特性相关联.
主要方法:
- 在UV光下在旋转的气中聚合HEMA配方.
- 制造具有多环环形杆的多孔段.
- 使用扫描电子显微镜进行微结构分析.
- 测量和建模模型蛋白质 (BSA,IgG) 运输 (扩散性,分割系数).
主要成果:
- 多孔的HEMA凝表现出模拟蛋白质的扩散控制释放.
- 在55%的含水量下聚合的凝显示出具有有限的辐射连接性的异型多孔性.
- 较高的水含量导致具有辐射和轴向两种方向相互连接的孔隙的同otropic 凝.
- 增加的含水量增加了孔隙体积,而分割系数仍然低于1.
结论:
- 旋转聚合提供了一种控制HEMA水凝微观结构和多孔性的方法.
- 凝微观结构,特别是孔隙互连性,显著影响蛋白质扩散性.
- 开发的方法允许根据特定的蛋白质运输要求量身定制HEMA水凝.
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