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Updated: Jun 18, 2025

Molecular Modulation by Lentivirus-Delivered Specific shRNAs in Endoplasmic Reticulum Stressed Neurons
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塞斯特林2驱动ER-phagy作为对蛋白质错误折叠的反应

Chiara De Leonibus1, Marianna Maddaluno2, Rosa Ferriero3

  • 1Telethon Institute of Genetics and Medicine (TIGEM), Pozzuoli, Italy; Department of Health Sciences, University of Basilicata, Potenza, Italy.

Developmental cell
|August 2, 2024
PubMed
概括

错误折叠的蛋白质通过SESTRIN2触发ER-phagy,抑制mTORC1并促进FAM134B. 这一途径清除ER储存障碍中的缺陷蛋白质,提供新的治疗点.

关键词:
储存障碍 储存障碍 储存障碍这是ER-phagy.在FAM134B中.美国联邦税务法 (TFEB)阿尔法1-抗素Z (阿尔法1-ATZ) 是一种抗素.自自是自的过程.原蛋白是一种原蛋白.细胞内膜网膜的内oplasmic网膜.在 mTORC1 的情况下,mTORC1 是质量控制质量控制质量控制

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