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在阻塞性呼吸道疾病中使用混合方法对EQ-5D-5L的替代时间框架和描述者的探索性研究
Ai-Ping Chua1, Mathieu F Janssen2, Ling Jie Cheng3
1Department of Medicine, JurongHealth Campus, National University Health System, Singapore.
概括
修改EQ-5D-5L问卷以更长的回忆期和频率尺度可能会提高其对慢性阻塞性呼吸道疾病 (OAD) 症状的测量. 这些变化改善了OAD患者的心理测量特性.
科学领域:
- 健康 结果 研究 研究 结果
- 患者报告的结果测量
背景情况:
- 具有"今天"回忆期的EQ-5D-5L可能无法充分捕捉慢性阻塞性呼吸道疾病 (OAD) 中的偶发症状和恶化.
- 改善健康状况问卷的测量特性对于在慢性疾病中进行准确评估至关重要.
研究的目的:
- 调查延长召回时间框架和改变响应尺度 (强度到频率) 是否可以提高EQ-5D-5L对OAD患者的测量特性.
- 为了比较修改后的EQ-5D-5L变体的性能与原始版本和经过验证的呼吸问卷.
主要方法:
- 一种混合方法设计,涉及患者和临床医生的采访,以确定首选的时间框架.
- 向OAD患者提供EQ-5D-5L变体,具有1周和4周的时间框架和原始/频率尺度.
- 使用相关性,ROC分析,ICC和Cohen's Kappa对上限效应,构造有效性,可靠性和响应能力进行比较.
主要成果:
- 与原来的EQ-5D-5L相比,经过修改的EQ-5D-5L变体显示出较低的天花板效应 (P < .001).
- 这些变体的可靠性与原来的EQ-5D-5L.相比或高于.
- 接收器运行特征 (ROC) 分析表明变体的c-统计值始终较高,表明响应性有所改善.
结论:
- 较长的时间框架和频率响应尺度可能会改善OAD患者的EQ-5D-5L的心理特征.
- 这些修改为捕捉慢性呼吸道疾病中的健康状况提供了潜在的增强.
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