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儿童慢性咳的危险因素:一个覆盖五大洲的元分析
KaiWen Zheng1, LinYan Tang1, Xiang Wang1
1School of Clinical Medicine, Shandong Second Medical University, Weifang, 261000, Shandong, China.
Respiratory medicine
|August 2, 2024
概括
喘,二氧化 (NO2),房屋改造,二手烟,物暴露,菌和年轻年龄是儿童慢性咳的关键危险因素. 需要进一步的研究来确认其他潜在的原因.
科学领域:
- 儿科 儿科 儿科
- 环境健康 环境健康
- 流行病学 流行病学
背景情况:
- 儿童慢性咳是多因素原因的常见问题.
- 确定特定的风险因素对于有效的预防和管理策略至关重要.
研究的目的:
- 进行元分析,确定儿童群体慢性咳的重大风险因素.
- 为医疗保健专业人员和公共卫生倡议提供基于证据的参考资料.
主要方法:
- 在PubMed,Web of Science,Cochrane和EMBASE数据库中进行了系统的文献搜索.
- 包括到2024年4月发表的观察性研究,由两个独立研究人员提取的数据.
- 随机效应模型被用于元分析,评估异质性,执行子组和灵敏度分析,并评估出版偏差.
主要成果:
- 该审查涵盖了18项涉及97,462名儿童的研究.
- 确定的重大风险因素包括喘 (OR=4.06),NO2暴露 (OR=1.19),房屋改造史 (OR=1.82),环境烟草烟雾 (OR=1.41),物暴露 (OR=1.56),菌暴露 (OR=1.64),以及1岁以下的年龄 (OR=3.19).
结论:
- 喘,NO2,家庭改造,环境烟草烟雾,物暴露,菌和年轻年龄 (<1岁) 是儿科慢性咳的确诊危险因素.
- 建议进行进一步的大规模多中心试验,以验证这些发现,并探索其他潜在的风险因素,因为在某些领域的证据有限.
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