3D打印的浮式药物输送系统中的当前趋势:全面审查
Gloria Mora-Castaño1, Juan Domínguez-Robles1, Achmad Himawan2
1Department of Pharmacy and Pharmaceutical Technology, Universidad de Sevilla, C/Profesor García González 2, 41012 Seville, Spain.
International journal of pharmaceutics
|August 2, 2024
概括
三维 (3D) 打印提供了一种创新的方法,可以创建个性化的胃食药物递送系统 (GRDDS). 这项技术可以开发浮动系统,以改善药物吸收和持续释放,解决胃肠道环境的变化.
科学领域:
- 制药技术 制药技术 制药技术
- 药物输送系统 药物输送系统
- 生物医学工程 生物医学工程
背景情况:
- 胃肠道 (GI) 药物吸收因性别,遗传学和疾病状况等因素而变化很大,通常导致生物可用性较低.
- 胃阻塞药物递送系统 (GRDDS) 旨在克服这些挑战,增强局部治疗并使药物持续释放.
- 浮式GRDDS在延长胃内停留时间和实现所需的释放配置文件方面特别有希望.
研究的目的:
- 系统地审查基于3D打印的设计,用于制造浮式GRDDS.
- 总结影响工业扩张浮力和持续释放的关键参数.
- 讨论3D打印药物输送系统的材料特性,生物相容性和安全考虑.
主要方法:
- 在浮式GRDDS中对3D打印应用的系统文献综述.
- 分析影响系统性能 (强度,药物释放) 的设计参数.
- 审查与生物相容性和安全相关的材料科学方面.
主要成果:
- 确定了浮动GRDDS的各种3D打印设计,突出了它们的多功能性.
- 总结了实现浮力和持续释放的关键因素,这对于扩大规模至关重要.
- 讨论了不同材料对药物释放动态,生物相容性和安全性的影响.
结论:
- 3D打印技术为制造个性化的浮式GRDDS提供了一个多功能平台.
- 了解关键的设计和材料参数对于3D打印药物输送系统的工业化至关重要.
- 对材料和制造工艺的进一步研究将优化这些先进的药物输送系统的有效性和安全性.
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