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Updated: Jun 18, 2025

In Vivo Nanovector Delivery of a Heart-specific MicroRNA-sponge
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依赖MFN2的线粒体功能障碍通过USP18/Twist1/miR-214通路导致Relm-β诱导的肺动脉高血压

Yan Wang1, Dong Han2, Limin Chai1

  • 1Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, PR China.

European journal of pharmacology
|August 2, 2024
PubMed
概括

类似于抵抗的分子β (Relm-β) 通过通过USP18/Twist1/miR-214通路促进细胞增殖来驱动肺动脉高血压,这减少了MFN2并导致线粒体裂变. 准这一轴为PAH提供了一个潜在的治疗策略.

关键词:
在MFN2中,MFN2是MFN2.肺动脉高血压是肺动脉高血压.雷尔姆-ββ是什么意思这就是Twist1的原因.USP18 美元

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