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创伤性脑损伤后前垂体功能障碍:一项前性研究

Ashwin Rai¹, Gopikrishnan Rajasekar¹, Jayaprakash Sahoo²

¹Department of Neurosurgery, Jawaharlal Institute of Post-graduate Medical Education and Research (JIPMER), Puducherry, India.

World neurosurgery

|August 2, 2024

概括

前垂体功能障碍在创伤性脑损伤 (TBI) 后很常见,急性影响超过80%. 在TBI患者中,甲状腺轴缺陷与较差的长期结果有关.

科学领域:

神经内分泌学神经内分泌学
创伤学创伤学创伤学

背景情况:

前垂体功能障碍是创伤性脑损伤 (TBI) 后残疾的重要原因.
了解其发病率和预后价值对于患者管理至关重要.

研究的目的:

为了评估前垂体功能障碍在中度至重度TBI中的发生率.
评估其在长期预测中的作用.
确定急性和慢性TBI阶段的诱导因素.

主要方法:

对216名中度至重度TBI患者进行前性队列研究.
在TBI后的72小时内 (急性) 和6个月 (慢性) 进行评估.
对前垂体轴的评估 (垂体下垂体,甲状腺,淋巴腺,上腺).

主要成果:

在急性阶段,82.4%的患者患有下垂体病,57.4%的患者患有甲状腺轴缺陷,54.2%的患者患有淋巴腺轴缺陷.
在慢性阶段,下位症降至59.3%,甲状腺轴缺陷降至24.4%,淋巴腺轴缺陷降至32.6%.
住院时甲状腺轴缺陷与6个月后更糟糕的修改兰金表得分相关.

结论:

甲状腺和淋巴激素轴最常受到TBI的影响.
在至少一个垂体轴的缺陷被观察到在82.4%急性和59.3%慢性.
甲状腺轴缺陷会对TBI患者的预后产生负面影响.

关键词:

上腺轴缺陷上腺轴缺乏前垂体功能障碍前垂体功能障碍发生性腺轴缺陷发生性腺轴缺陷在TBI后出现的hypopituitarism.甲状腺轴缺陷甲状腺轴缺陷

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Traumatic Brain Injury l: Introduction

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DefinitionTraumatic brain injury, or TBI, is a disturbance of normal brain function induced by an external mechanical force, such as a direct blow to the head or a penetrating injury. It can affect both brain structure and function, producing a wide range of clinical outcomes. TBI is a heterogeneous condition, meaning its effects may differ based on the type, location, and severity of the injury.Basis of ClassificationTBI is classified based on severity, injury mechanism, or pathophysiology. In...