Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Factors Affecting Protein-Drug Binding: Patient-Related Factors01:29

Factors Affecting Protein-Drug Binding: Patient-Related Factors

479
Protein-drug binding, a pivotal aspect of pharmacokinetics, is subject to considerable variability influenced by an array of patient-related factors. The intricate interplay of age, individual differences, and pathological conditions significantly impact the binding dynamics and subsequent pharmacological effects.
Age stands as a key determinant in protein-drug binding. Neonates, characterized by low albumin content, experience heightened concentrations of unbound drugs such as phenytoin and...
479
Aneurysm IV: Nursing Management01:22

Aneurysm IV: Nursing Management

625
Vigilant monitoring for aneurysm rupture is essential for patients undergoing aortic surgery.Preoperative Nursing ManagementContinuously monitor the patient for manifestations of aneurysm rupture, such as pallor, weakness, tachycardia, hypotension, abdominal, back, groin, or periumbilical pain, changes in consciousness, and a pulsating abdominal mass. Regularly assess the patient's peripheral pulses.Instruct the patient to consume a clear liquid diet the day before surgery and administer...
625
Cerebral Edema ll: Pathophysiology01:22

Cerebral Edema ll: Pathophysiology

31
Vasogenic edema is a major form of cerebral edema characterized by abnormal accumulation of fluid in the brain’s extracellular space due to disruption of the blood–brain barrier (BBB). The BBB is a specialized structure composed of endothelial cells connected by tight junctions, supported by astrocytic endfeet and a basement membrane. Under normal conditions, it tightly regulates the movement of ions, proteins, and solutes between the bloodstream and brain parenchyma. When this...
31

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Functional connectivity changes in patients with absence epilepsy studied using resting-state functional MRI.

Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia·2012
Same author

Quantitative analysis of mitral valve morphology in mitral valve prolapse with real-time 3-dimensional echocardiography: importance of annular saddle shape in the pathogenesis of mitral regurgitation.

Circulation·2012
Same author

Interval cancers in nasopharyngeal carcinoma screening: comparing two screening intervals after a negative initial screening result.

Journal of medical screening·2012
Same author

Two Epstein-Barr virus-related serologic antibody tests in nasopharyngeal carcinoma screening: results from the initial phase of a cluster randomized controlled trial in Southern China.

American journal of epidemiology·2012
Same author

MALT1 small molecule inhibitors specifically suppress ABC-DLBCL in vitro and in vivo.

Cancer cell·2012
Same author

Extraction and characterization of extracellular polymeric substances in biofilm and sludge via completely autotrophic nitrogen removal over nitrite system.

Applied biochemistry and biotechnology·2012

相关实验视频

Updated: May 6, 2026

A Craniotomy Surgery Procedure for Chronic Brain Imaging
09:25

A Craniotomy Surgery Procedure for Chronic Brain Imaging

Published on: February 15, 2008

64.1K

术后白蛋白降低与为脑瘤进行脑切除术的患者的结果之间的关联.

Yangchun Xiao1, Yaqing Zhao2, Xin Cheng2

  • 1Center for Evidence-Based Medical, Clinical Medical College and Affiliated Hospital of Chengdu University, Chengdu, Sichuan, China.

World neurosurgery
|August 2, 2024
PubMed
概括

脑瘤骨切除术后的三角白蛋白 (ΔAlb) 增加与更高的30天死亡率有关. 即使是轻微的 ΔAlb 也会增加风险,无论阿尔伯明水平如何低,这表明它对患者结果的预测价值.

关键词:
大脑瘤是什么?进行了切除术 (craniotomy).德尔塔专辑蛋白是什么?死亡率 死亡率 死亡率术后的治疗方法

更多相关视频

Assessment of Blood-brain Barrier Permeability by Intravenous Infusion of FITC-labeled Albumin in a Mouse Model of Neurodegenerative Disease
07:22

Assessment of Blood-brain Barrier Permeability by Intravenous Infusion of FITC-labeled Albumin in a Mouse Model of Neurodegenerative Disease

Published on: November 8, 2017

9.9K
Quantitative Measurement of Intrathecally Synthesized Proteins in Mice
08:23

Quantitative Measurement of Intrathecally Synthesized Proteins in Mice

Published on: November 29, 2019

10.9K

相关实验视频

Last Updated: May 6, 2026

A Craniotomy Surgery Procedure for Chronic Brain Imaging
09:25

A Craniotomy Surgery Procedure for Chronic Brain Imaging

Published on: February 15, 2008

64.1K
Assessment of Blood-brain Barrier Permeability by Intravenous Infusion of FITC-labeled Albumin in a Mouse Model of Neurodegenerative Disease
07:22

Assessment of Blood-brain Barrier Permeability by Intravenous Infusion of FITC-labeled Albumin in a Mouse Model of Neurodegenerative Disease

Published on: November 8, 2017

9.9K
Quantitative Measurement of Intrathecally Synthesized Proteins in Mice
08:23

Quantitative Measurement of Intrathecally Synthesized Proteins in Mice

Published on: November 29, 2019

10.9K

科学领域:

  • 神经外科 神经外科
  • 在瘤学瘤学.
  • 临床生物化学 临床生物化学

背景情况:

  • 血清白蛋白是营养状况的关键指标.
  • 低的术后白蛋白水平和显著下降 (三角白蛋白,ΔAlb) 与不良结果相关.
  • ΔAlb可以预测并发症和死亡率,即使手术后白蛋白超过30g/L.

研究的目的:

  • 为了研究 ΔAlb 与脑瘤骨切除术后患者的结果之间的关联.
  • 为了确定 ΔAlb 是否预测该患者队列中的30天死亡率.

主要方法:

  • 对9660名因脑瘤而接受骨切除术的患者进行了回顾性分析.
  • 根据ΔAlb水平,患者被分为四组:<5g/L,5-9.9g/L,10-14.9g/L和≥15g/L.
  • 主要终点:手术后30天死亡率.

主要成果:

  • 观察到的 ΔAlb 中位数为 7.3 g/L.
  • 增加的 ΔAlb 与更高的 30 天死亡率显著相关 (ORs 从 1.93 到 7.26, P < 0.01).
  • ΔAlb>5g/L是死亡率的强有力的预测指标,即使nadir白蛋白>30g/L (OR1.84,P=0.014).

结论:

  • 在脑瘤骨切除术后, ΔAlb 的轻微增加与30天死亡率的增加有关.
  • ΔAlb预测死亡率,即使nadir白蛋白水平保持在30g/L以上.
  • ΔAlb还与术后并发症和延长住院时间相关.