目前的趋势是,Biapenem易感性和盘扩散断点在肠杆菌和Pseudomonas aeruginosa中的现有趋势
Yamuna Devi Bakthavatchalam1, Lydia Jennifer1, Fiza Abdullah1
1Department of Clinical Microbiology, Christian Medical College, Vellore, India.
Indian journal of medical microbiology
|August 2, 2024
概括
比亚胺显示出有效的体外活性对抗具有挑战性的阴性细菌,包括那些产生扩展光谱β-乳酸酶 (ESBLs) 和卡巴酶的细菌. 建议使用10微克的磁盘度来准确测试这些耐药病原体的敏感性.
科学领域:
- 微生物学 微生物学
- 传染性疾病 传染性疾病
- 抗微生物耐药性 抗微生物耐药性
背景情况:
- 一种新型抗生素Biapenem在印度已被批准用于治疗复杂的尿路感染 (cUTI).
- 关于其对当代印度格兰阴性分离物的有效性存在有限的数据,特别是产生ESBL的肠杆菌.
研究的目的:
- 评估来自印度的产生ESBL和/或产生OXA-1/ampC的肠杆菌和Pseudomonas aeruginosa的biapenem的体外活性.
- 为了评估10微克的双胺磁盘对敏感性测试的可靠性.
主要方法:
- 使用微稀释方法来确定对biapenem和对比剂的敏感性.
- 多重PCR被用于检测ESBL (SHV,TEM,CTX-M),OXA-1和ampC基因.
主要成果:
- 比亚胺在体外表现出与美罗胺相比的活性,对抗耐药的大肠杆菌,肺炎和P. aeruginosa.
- 10微克的双胺盘度显示,这些关键细菌分离物的测试没有错误率.
结论:
- 比亚尼姆在体外对当代耐药格兰氏阴性病原体表现出显著的活性.
- 对于敏感性测试,10μg的双胺盘度是准确的,因此需要调整盘扩散断点以进行解释.
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