慢性阻塞性肺病和阻塞性睡眠呼吸暂停重叠综合征:关于流行病学,病理生理学和管理的最新情况
Benjamin H M Nguyen1, Patrick B Murphy2, Brendon J Yee3
1Department of Thoracic Medicine, Level 4 Xavier Building, St Vincent's Hospital, 390 Victoria Street, Darlinghurst, NSW 2010, Australia; Department of Respiratory and Sleep Medicine, Royal Prince Alfred Hospital, Level 11 Royal Prince Alfred Hospital, Missenden Road, Camperdown, NSW 2050, Australia; Faculty of Medicine and Health, Sydney Medical School, Sydney Medical School Central Sydney, The University of Sydney, NSW 2006, Australia; The Woolcock Institute of Medical Research, Macquarie University, 2 Innovation Road, Macquarie Park, NSW 2113, Australia.
慢性阻塞性肺病 (COPD) 和阻塞性睡眠呼吸暂停 (OSA) 重叠综合征 (OVS) 是常见的,并与炎症和不良结果有关. 阳性气道压力可以改善OVS患者的生存率.
科学领域:
- 肺部病理学 肺部病理学
- 睡眠医学 睡眠医学
- 心脏病学 心脏病学
背景情况:
- 慢性阻塞性肺病 (COPD) 和阻塞性睡眠呼吸暂停 (OSA) 经常同时存在,形成重叠综合征 (OVS).
- OVS与显著的夜间低氧化和全身炎症有关.
- 心血管疾病在OVS患者中非常普遍,导致死亡率增加.
研究的目的:
- 提供对当前对OVS的理解的全面审查.
- 总结一下OVS的流行,病理生理学,诊断和治疗情况.
- 突出OVS的临床影响和未来研究方向.
主要方法:
- 对COPD和OSA研究的文献综述重叠.
- 综合了关于OVS流行,临床特征和结果的数据.
- 对当前治疗策略和证据的分析.
主要成果:
- 在COPD和OSA群体中,OVS的流行率很高.
- OVS的特点是严重的夜间氧气不和和升高的全身炎症.
- 观察数据表明,正气道压力 (PAP) 治疗可以提高生存率并减少慢性肺炎恶化.
结论:
- OVS是一种与不良健康结果相关的显著临床疾病.
- 需要进一步的随机对照试验来验证PAP治疗在OVS中的好处.
- 有效管理OVS对于改善患者预后至关重要.
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