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相关概念视频

Obesity01:24

Obesity

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The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
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Overview of Lipid Metabolism01:24

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Lipid metabolism is a crucial process in the human body that involves the synthesis and degradation of lipids. This process is essential for energy production, cell membrane formation, and hormone production, among other functions.
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
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Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
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The hypodermis (the subcutaneous layer or superficial fascia) is present directly below the dermis. It connects the skin to the underlying fascia (fibrous tissue) of the bones and muscles. It is not strictly a part of the skin, although the border between the hypodermis and dermis can be difficult to distinguish. The hypodermis consists of well-vascularized, loose, areolar connective tissue and adipose tissue, which functions as a mode of fat storage and provides insulation and cushioning for...
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相关实验视频

Updated: Jun 18, 2025

Mechanism of Regulation of Adipocyte Numbers in Adult Organisms Through Differentiation and Apoptosis Homeostasis
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肥胖如何影响脂肪细胞周转率

Sang Mun Han1, Hahn Nahmgoong1, Kyung Min Yim1

  • 1National Leader Research Initiatives Center for Adipocyte Structure and Function, Institute of Molecular Biology and Genetics, School of Biological Sciences, Seoul National University, Seoul 08826, Republic of Korea.

Trends in endocrinology and metabolism: TEM
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概括

脂肪细胞的周转对于脂肪组织的健康至关重要,特别是在代谢压力期间. 本综述详细介绍了死亡脂肪细胞如何被清除并被新脂肪细胞取代,这一过程对于维持组织平衡至关重要.

关键词:
脂肪细胞的周转率脂肪组织的可塑性脂肪组织重塑的重塑在iNKT细胞中.肥胖症 肥胖症 肥胖症 肥胖症

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科学领域:

  • 细胞和分子生物学 细胞和分子生物学
  • 身体生理学 身体生理学
  • 代谢健康 代谢健康

背景情况:

  • 细胞循环对于组织平衡和完整性至关重要.
  • 脂肪细胞周转占人体细胞质量周转的4%,在代谢压力期间对脂肪组织功能至关重要.
  • 肥胖会破坏脂肪组织的微环境,导致脂肪细胞死亡.

研究的目的:

  • 审查当前对脂肪细胞周转的理解.
  • 讨论参与脂肪细胞死亡,清除和再生的关键参与者和监管机制.
  • 要突出脂肪细胞周转在维护脂肪组织恒常状态中的策划性质.

主要方法:

  • 这是一篇综述性文章,综合了现有研究.
  • 通过文献分析确定了关键参与者和监管机制.
  • 脂肪细胞循环的过程被分为不同的阶段来研究:死亡,清除和再生.

主要成果:

  • 巨细胞清除死亡的脂肪细胞,形成冠状结构.
  • 脂肪干细胞和原始细胞在脂肪生成的利基中产生新的脂肪细胞.
  • 脂肪细胞死亡,清除和脂肪生成是复杂协调的过程.

结论:

  • 脂肪细胞周转是一个精心策划的过程,对脂肪组织恒温至关重要.
  • 了解脂肪细胞循环的机制对于解决肥胖中代谢功能障碍至关重要.
  • 对关键参与者和监管途径的进一步研究可以为治疗策略提供信息.