临床,成像和技术因素与成功的基因组剖析与关联的前列腺癌的骨活检组织在前列腺癌
Fourat Ridouani1, H Alberto Vargas2, Daniel J Holzwanger3
1Department of Radiology, Interventional Radiology Division, Memorial Sloan Kettering Cancer, New York, NY, USA.
European urology oncology
|August 2, 2024
概括
转移性割抵抗性前列腺癌 (mCRPC) 骨活检的成功基因组分析取决于选择具有高代谢活性和较低CT衰减的部位. 这提高了获得足够瘤材料的大面板DNA测序和个性化治疗的机会.
科学领域:
- 在瘤学瘤学.
- 基因组学就是基因组学.
- 医疗成像医学成像
背景情况:
- 转移性割抵抗性前列腺癌 (mCRPC) 的基因组分析通常依赖于骨质转移.
- 从骨病变中获取用于基因组分析的组织具有挑战性.
- 优化活检部位选择和技术对于识别可操作突变至关重要.
研究的目的:
- 确定影响mCRPC患者骨活检成功大面板DNA测序的关键参数.
- 为指导转移部位选择和活检技术的临床决策.
主要方法:
- 在2014年至2018年期间,对243名患有mCRPC的男性进行了269次骨活检的分析.
- 评估临床,成像 (骨扫描,FDG-PET,CT,MRI) 和技术活检参数.
- 单变量和多变量统计分析以确定与成功基因组分析的关联.
主要成果:
- 59%的活检产生了足够的瘤物质用于基因组分析.
- 多变量分析确定了较高的FDG最大标准化吸收值 (OR 7.51),更多的活检样本 (OR 4.73),以及较低的平均CT衰减 (OR 0.4) 作为测序成功的显著预测因素.
- 在单变量分析中,FDG-PET阳性,CT衰减和CT形态显著.
结论:
- 来自高代谢活性 (FDG-PET阳性) 和较低CT衰减的部位的骨活检与基因组分析的更高成功率有关.
- 增加活检样本的数量也提高了成功测序的可能性.
- 这些发现有助于选择最佳的活检部位和技术,以进行个性化的mCRPC治疗计划.
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