Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

High-fidelity fast fluorescence lifetime imaging by event-based denoising.

Nature biotechnology·2026
Same author

High numerical aperture confocal volumetric mesoscope reveals mesoscale subcellular dynamics in vivo.

Nature biotechnology·2026
Same author

Unsupervised transfer learning enables multi-animal tracking without training annotation.

Nature methods·2026
Same author

Dynamic neuronal ensembles encode burst-suppression revealed by cortex-wide optical-electrical interfaces.

Nature communications·2026
Same author

High-fidelity intravital imaging of biological dynamics with latent-space-enhanced digital adaptive optics.

Nature biotechnology·2026
Same author

Deeper detection limits in astronomical imaging using self-supervised spatiotemporal denoising.

Science (New York, N.Y.)·2026

相关实验视频

Updated: Jun 18, 2025

Spatial Profiling of Protein and RNA Expression in Tissue: An Approach to Fine-Tune Virtual Microdissection
09:19

Spatial Profiling of Protein and RNA Expression in Tissue: An Approach to Fine-Tune Virtual Microdissection

Published on: July 6, 2022

4.9K

通过使用深度生成模型在空间奥米克平台上的增强分辨率进行组织表征.

Bohan Li1, Feng Bao2,3,4, Yimin Hou1

  • 1School of Artificial Intelligence, Beihang University, Beijing, China.

Nature communications
|August 2, 2024
PubMed
概括

soScope 提高了各种分子形状的空间数据质量和分辨率. 这种统一的框架改善了组织架构的识别,并纠正了跨不同空间技术的偏见.

更多相关视频

Author Spotlight: Advanced Techniques for Characterizing Tissue Mineralization in Bone Regeneration Research
07:29

Author Spotlight: Advanced Techniques for Characterizing Tissue Mineralization in Bone Regeneration Research

Published on: September 27, 2024

695
Tissue Characterization after a New Disaggregation Method for Skin Micro-Grafts Generation
09:30

Tissue Characterization after a New Disaggregation Method for Skin Micro-Grafts Generation

Published on: March 4, 2016

21.5K

相关实验视频

Last Updated: Jun 18, 2025

Spatial Profiling of Protein and RNA Expression in Tissue: An Approach to Fine-Tune Virtual Microdissection
09:19

Spatial Profiling of Protein and RNA Expression in Tissue: An Approach to Fine-Tune Virtual Microdissection

Published on: July 6, 2022

4.9K
Author Spotlight: Advanced Techniques for Characterizing Tissue Mineralization in Bone Regeneration Research
07:29

Author Spotlight: Advanced Techniques for Characterizing Tissue Mineralization in Bone Regeneration Research

Published on: September 27, 2024

695
Tissue Characterization after a New Disaggregation Method for Skin Micro-Grafts Generation
09:30

Tissue Characterization after a New Disaggregation Method for Skin Micro-Grafts Generation

Published on: March 4, 2016

21.5K

科学领域:

  • 空间奥米克斯 空间奥米克斯
  • 计算生物学是一种计算生物学.
  • 生物信息学是一种生物信息学.

背景情况:

  • 空间奥米克技术将超越转录组学的分子类别描述.
  • 局限的空间分辨率阻碍了详细的组织架构表征.
  • 现有的计算方法缺乏适应多样化的空间数据的适应性.

研究的目的:

  • 介绍soScope,一个统一的生成框架.
  • 提高数据质量和空间分辨率,用于各种空间数据.
  • 解决当前计算方法的局限性.

主要方法:

  • soScope集成多式联络组织信息 (omics,空间关系,图像).
  • 通过使用omics特定的建模和分发先例,在增强的分辨率上共同推断omics配置文件.
  • 在Visium,Xenium,空间-CUT&Tag和幻灯片-DNA/RNA-seq平台上进行评估.

主要成果:

  • 改善了对具有生物意义的肠道和脏结构的识别.
  • 揭示了精细的胚胎心脏结构,在原始分辨率下无法分辨.
  • 纠正了测序和处理中的样本和技术偏差.
  • 扩展到空间多态 (例如,CITE-seq,ATAC-seq) 进行同时增强.

结论:

  • soScope是一个多功能工具,用于改进空间omics数据利用.
  • 在各种空间电脑技术中提高分辨率和质量.
  • 促进对组织结构和生物过程的更深入的理解.