通过MRI诊断ASD:系统性审查和元分析
Sjir J C Schielen1, Jesper Pilmeyer2, Albert P Aldenkamp2,3
1Department of Electrical Engineering, Eindhoven University of Technology, Eindhoven, the Netherlands. s.j.c.schielen@tue.nl.
Translational psychiatry
|August 2, 2024
概括
磁共振成像 (MRI) 显示出诊断自闭症谱系障碍 (ASD) 的潜力,达到76%的灵敏度和76%的特异性. 虽然有希望,但异质性和泛化问题目前限制了临床应用.
科学领域:
- 神经成像是一种神经成像.
- 诊断的准确性 诊断的准确性
- 自闭症谱系障碍研究研究
背景情况:
- 目前的自闭症谱系障碍 (ASD) 诊断依赖于主观观察.
- 客观的诊断方法,特别是使用磁共振成像 (MRI),是非常理想的.
研究的目的:
- 系统地审查和分析使用MRI诊断ASD的研究.
- 描述基于MRI的ASD诊断现状,包括性能指标和解释.
- 在MRI诊断研究中分析子组和统计异质性.
主要方法:
- 使用静止状态MRI用于二分型ASD诊断的研究的系统审查和元分析.
- 在科学网和PubMed数据库中进行了搜索.
- 使用经过修订的诊断准确性研究质量评估工具评估研究质量和偏差风险.
- 在数据合成中采用双变的随机效应模型.
主要成果:
- 包括134项研究和159项实验,分析了4982名参与者的数据 (2439名患有自闭症,2543名对照).
- 综合诊断性能:76.0%的灵敏度,75.7%的特异性,曲线下的面积为0.823.
- 在概括中显著的异质性和不确定性限制了信心和子组分析.
结论:
- 基于MRI的方法显示诊断性能接近ASD的临床实用性.
- 目前的局限性包括异质性和概括不确定性,需要进一步研究.
- 尽管存在障碍,但MRI在未来的ASD诊断中具有显著的临床应用潜力.
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