Jove
Visualize
联系我们

相关概念视频

Intralumenal Vesicles and Multivesicular Bodies01:38

Intralumenal Vesicles and Multivesicular Bodies

3.4K
Intraluminal vesicles (ILVs) are small vesicles 50-80 nm in diameter formed during the maturation of early endosomes. A specialized endosome containing numerous ILVs is called a multivesicular body (MVB). ILVs contain internalized molecules such as antigens, nucleic acids, proteins, and metabolites. Some of these molecules are released from the MVBs inside exosomes and are transported to other cells. Other MVBs contain molecules that are retained in the ILVs and are later degraded within the...
3.4K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Small molecule stabilization of diverse amyloidogenic immunoglobulin light chains revealed by hydrogen-deuterium exchange mass spectrometry.

Journal of molecular biology·2026
Same author

Blocking RAN translation without altering repeat RNAs rescues <i>C9ORF72</i>-related ALS and FTD phenotypes.

Science (New York, N.Y.)·2026
Same author

Energy stress activates AMPK to arrest mitochondria via phosphorylation of TRAK1.

The Journal of cell biology·2026
Same author

Mechanisms of HSV-1 helicase-primase inhibition and replication fork complex assembly.

bioRxiv : the preprint server for biology·2026
Same author

A droplet microfluidics-based platform for generating target-specific, natively-paired immune libraries and identifying potent and developable antibodies.

Scientific reports·2026
Same author

Epstein-Barr virus exploits desmocollin 2 as the principal epithelial cell entry receptor.

Nature microbiology·2025
Same journal

Unlocking the capacity of Mn-based Prussian blue cathodes in capacitive deionization.

Nature communications·2026
Same journal

Scaling biodiversity-stability relationships from populations to meta-communities across trophic levels.

Nature communications·2026
Same journal

Thermodynamically programmed one-pot CRISPR platform for point-of-care SNP genotyping.

Nature communications·2026
Same journal

Engineering all-organic electrocatalysts with asymmetric dual-active sites for uncommon oxygen-evolving pathway.

Nature communications·2026
Same journal

Rapid GC content evolution in rice through GC-biased gene conversion and selection for translation efficiency.

Nature communications·2026
Same journal

Declines in organic matter persistence with increased soil carbon.

Nature communications·2026
查看所有相关文章
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关实验视频

Updated: Jun 18, 2025

Analysis of Group IV Viral SSHHPS Using In Vitro and In Silico Methods
10:40

Analysis of Group IV Viral SSHHPS Using In Vitro and In Silico Methods

Published on: December 21, 2019

26.0K

通过东部马类脑炎病毒识别VLDLR的结构基础

Pan Yang1, Wanyu Li1, Xiaoyi Fan1

  • 1Department of Microbiology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.

Nature communications
|August 2, 2024
PubMed
概括
此摘要是机器生成的。

东部马脑炎病毒 (EEEV) 和塞米利基森林病毒 (SFV) 使用不同的结合方式与相同的细胞受体,VLDLR.相互作用. 这一发现揭示了病毒获得与LDLR相关的蛋白质作为受体的低进化障碍.

更多相关视频

Using Reverse Genetics to Manipulate the NSs Gene of the Rift Valley Fever Virus MP-12 Strain to Improve Vaccine Safety and Efficacy
09:13

Using Reverse Genetics to Manipulate the NSs Gene of the Rift Valley Fever Virus MP-12 Strain to Improve Vaccine Safety and Efficacy

Published on: November 1, 2011

17.4K
Bacterial Artificial Chromosomes: A Functional Genomics Tool for the Study of Positive-strand RNA Viruses
12:20

Bacterial Artificial Chromosomes: A Functional Genomics Tool for the Study of Positive-strand RNA Viruses

Published on: December 29, 2015

21.4K

相关实验视频

Last Updated: Jun 18, 2025

Analysis of Group IV Viral SSHHPS Using In Vitro and In Silico Methods
10:40

Analysis of Group IV Viral SSHHPS Using In Vitro and In Silico Methods

Published on: December 21, 2019

26.0K
Using Reverse Genetics to Manipulate the NSs Gene of the Rift Valley Fever Virus MP-12 Strain to Improve Vaccine Safety and Efficacy
09:13

Using Reverse Genetics to Manipulate the NSs Gene of the Rift Valley Fever Virus MP-12 Strain to Improve Vaccine Safety and Efficacy

Published on: November 1, 2011

17.4K
Bacterial Artificial Chromosomes: A Functional Genomics Tool for the Study of Positive-strand RNA Viruses
12:20

Bacterial Artificial Chromosomes: A Functional Genomics Tool for the Study of Positive-strand RNA Viruses

Published on: December 29, 2015

21.4K

科学领域:

  • 病毒学 病毒学
  • 结构生物学 结构生物学
  • 分子相互作用 分子相互作用

背景情况:

  • 东部马脑炎病毒 (EEEV) 是一种高度毒性的阿尔法病毒,在人类幸存者中引起严重的神经后果.
  • 阿尔法病毒进入宿主细胞是通过尖端糖蛋白 (E2和E1) 介导的,这些糖蛋白结合细胞受体并促进膜融合.
  • 非常低密度脂蛋白受体 (VLDLR) 和阿波利波蛋白E受体2 (ApoER2) 之前被确定为EEEV和塞米利基森林病毒 (SFV) 的细胞受体.

研究的目的:

  • 阐明EEEV和SFV与它们共享的细胞受体结合的结构基础,VLDLR.
  • 了解底层的分子机制阿尔法病毒-受体相互作用及其进化影响.

主要方法:

  • 使用单颗粒冷电子显微镜 (cryo-EM) 确定了EEV和SFV尖端糖蛋白的结构,这些糖蛋白与VLDLR联体结合域复合在一起.
  • 对病毒受体复合物的比较结构分析.

主要成果:

  • 冷-EM结构显示,EEEV和SFV通过不同的结合方式与VLDLR连接体结合域结合.
  • 尽管结合方式不同,但两种病毒都使用相同的细胞受体VLDLR.

结论:

  • 与病毒尖端蛋白相关的LDLR蛋白的灵活结合模式和小的相互作用足迹有助于它们被各种病毒采用为细胞受体.
  • 这种适应性表明阿尔法病毒利用LDLR家族成员的进化障碍很低,这有助于它们的广泛宿主范围和出现潜力.