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Updated: Jun 18, 2025

Using Next Generation Sequencing to Identify Mutations Associated with Repair of a CAS9-induced Double Strand Break Near the CD4 Promoter
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高复杂度的DNA双链断裂是替代端连接选择的关键

Zhiyang Hou1,2, Tianxiang Yu1,2, Qiyi Yi3

  • 1Key Laboratory of High Magnetic Field and Ion Beam Physical Biology, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, China.

Communications biology
|August 2, 2024
PubMed
概括

大肠杆菌中的一个新的记者系统揭示了复杂的DNA双链断裂 (DSB) 有利于替代端结合 (A-EJ) 途径. 这种途径使用独特的修复机制,并与同源重组相竞争.

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