聚二 (PCB) 和二氧化与代谢综合征 (METS) 的关联:系统性审查和元分析
Mohd Danial Mohd Efendy Goon1, Sarah Zulkifli1,2,3, Siti Suhana Abdullah Soheimi2,3
1Institute of Pathology, Laboratory and Forensic Medicine (I-PPerFoRM), Universiti Teknologi MARA (UiTM), Sungai Buloh Campus, 47000, Sungai Buloh, Selangor, Malaysia.
Scientific reports
|August 2, 2024
概括
多双 (PCB) 与糖尿病有着强烈的联系,但与其他代谢综合征 (MetS) 因素的联系较弱. 暴露于二氧化物与MetS的相关性很弱. 医疗保健提供者应评估患者暴露的风险.
科学领域:
- 环境健康 环境健康
- 内分泌学 在内分泌学.
- 流行病学 流行病学
背景情况:
- 多双 (PCB) 和二氧化是持续性内分泌干扰化学物质 (EDC).
- EDC与代谢综合征 (MetS) 和其组成部分的风险增加有关.
研究的目的:
- 系统地审查和元分析PCB和二氧化物暴露与MetS之间的关联.
- 评估PCB和二氧化物与METS风险因素之间的关系:肥胖,高三糖血症 (HTG),高血压 (HTN) 和糖尿病 (DM).
主要方法:
- 在2023年之前发表的流行病学研究的系统审查和元分析.
- 在三个电子数据库中搜索相关研究.
- 随机效应元分析模型用于计算几率比率 (OR) 和95%置信区间 (CI);使用Egger测试评估的出版偏差.
主要成果:
- 纳入了11项研究,共有40528名参与者.
- 在PCB暴露和DM (OR = 3.593) 之间发现了强烈的关联.
- 在PCB暴露和肥胖 (OR = 1.875),HTN (OR = 1.335),和HTG (OR = 1.611) 之间观察到弱相关性.
- PCB 与 MetS 的相关性较弱 (OR = 1.162),而二氧化与 MetS 的相关性较强 (OR = 2.742).
- 亚洲人中的DM和北美人的HTG与PCB暴露有关.
结论:
- 在PCB暴露和DM之间存在显著的关系.
- PCB,MetS和其他危险因素之间的关联不那么明显.
- 暴露于二氧化物显示出与MetS的弱相关性.
- 临床医生应考虑评估患者对PCB和二氧化的暴露,以进行有针对性的干预.
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